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Complications of pelvic radiation in patients treated for gynecologic malignancies

Viswanathan, Akila N. ; Lee, Larissa J. ; Eswara, Jairam R. ; Horowitz, Neil S. ; Konstantinopoulos, Panagiotis A. ; Mirabeau‐Beale, Kristina L. ; Rose, Brent S. ; von Keudell, Arvind G. ; Wo, Jennifer Y.

Cancer, 2014-12, Vol.120 (24), p.3870-3883 [Periódico revisado por pares]

Hoboken, NJ: Wiley-Blackwell

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Título:
Complications of pelvic radiation in patients treated for gynecologic malignancies
Autor: Viswanathan, Akila N. ; Lee, Larissa J. ; Eswara, Jairam R. ; Horowitz, Neil S. ; Konstantinopoulos, Panagiotis A. ; Mirabeau‐Beale, Kristina L. ; Rose, Brent S. ; von Keudell, Arvind G. ; Wo, Jennifer Y.
Assuntos: Biological and medical sciences ; Brachytherapy - adverse effects ; Female ; Gastrointestinal Diseases - epidemiology ; Gastrointestinal Diseases - etiology ; Gastrointestinal Diseases - therapy ; Genital Neoplasms, Female - radiotherapy ; gynecologic cancer ; Humans ; Incidence ; Medical sciences ; morbidity ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Pelvis - radiation effects ; radiation ; Radiation Dosage ; Radiation Injuries - complications ; Radiation Injuries - epidemiology ; toxicity ; Tumors
É parte de: Cancer, 2014-12, Vol.120 (24), p.3870-3883
Notas: We thank Barbara Silver and Remi Nout, MD for reviewing the article.
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Descrição: Radiation therapy is a critical treatment modality in the management of patients with gynecologic tumors. New highly conformal external‐beam and brachytherapy techniques have led to important reductions in recurrence and patient morbidity and mortality. However, patients who receive pelvic radiation for gynecologic malignancies may experience a unique constellation of toxicity because of the anatomic locations, combination with concurrent chemotherapy and/or surgery, as well as potential surgical interventions. Although side effects are often categorized into acute versus late toxicities, several late toxicities represent continuation and evolution of the same pathologic process. Comorbidities and radiation dose can significantly increase the risk of morbidity. Current understanding of the incidence of various morbidities in patients treated with current radiation techniques for gynecologic malignancies, the impact of chemotherapy and surgery, treatment options for those effects, and future areas of research are highlighted. Cancer 2014;120:3870–3883. © 2014 American Cancer Society. Modern radiotherapy techniques, including highly conformal radiation and image‐guided conformal brachytherapy, may reduce the risk of radiation‐related side effects. The management of side effects, including surgical and chemotherapeutic implications, is discussed.
Editor: Hoboken, NJ: Wiley-Blackwell
Idioma: Inglês

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Complications of pelvic radiation in patients treated for gynecologic malignancies

Viswanathan, Akila N. ; Lee, Larissa J. ; Eswara, Jairam R. ; Horowitz, Neil S. ; Konstantinopoulos, Panagiotis A. ; Mirabeau‐Beale, Kristina L. ; Rose, Brent S. ; von Keudell, Arvind G. ; Wo, Jennifer Y.

Hoboken, NJ: Wiley-Blackwell

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