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Equine Grass Sickness in Scotland: A Case-Control Study of Environmental Geochemical Risk Factors

Wylie, C.E. ; Shaw, D.J. ; Fordyce, F.M. ; Lilly, A. ; McGorum, B.C.

Equine veterinary journal, 2014-09, Vol.46 (S47), p.21-21 [Periódico revisado por pares]

Fordham: Blackwell Publishing Ltd

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  • Título:
    Equine Grass Sickness in Scotland: A Case-Control Study of Environmental Geochemical Risk Factors
  • Autor: Wylie, C.E. ; Shaw, D.J. ; Fordyce, F.M. ; Lilly, A. ; McGorum, B.C.
  • Assuntos: Studies
  • É parte de: Equine veterinary journal, 2014-09, Vol.46 (S47), p.21-21
  • Notas: ArticleID:EVJ12323_48
    istex:07FA1B6781BFE5009CC08AB7F0FF17E0B306CBB9
    ark:/67375/WNG-MSDGK56H-X
  • Descrição: Reasons for performing study Epidemiological investigations suggest that soil macro‐ and micro‐nutrients may be a trigger for the occurrence of equine grass sickness (EGS). However, there is limited information regarding relationships between exposure to geochemical elements and the occurrence of EGS. Objectives To determine whether the geographical distribution of EGS cases referred to the Royal (Dick) School of Veterinary Studies was associated with the presence or absence of particular geochemical elements in the environment. Study design A retrospective time‐matched case–control study. Methods 455 EGS geo‐referenced cases were identified between 1 January 1990 and 1 June 2006. Each case had 2 time‐matched geo‐referenced controls (n = 910). For study purposes, cases or controls originating outwith Scotland were excluded. Environmental concentrations of a range of elements, most with known biological function, were collated from 2 geochemical point datasets and spatially extrapolated giving continuous cover across Scotland: the British Geological Survey (BGS) Geochemical Baseline Survey of the Environment (G‐BASE) stream sediment dataset and the James Hutton Institute (JHI), National Soil Inventory of Scotland (NSIS). Data were analysed using multivariable conditional logistic regression. Results Statistically significant associations were obtained between the distribution of EGS cases and (i) higher environmental levels of Ca, K, Mo, Na, Se and Ti, and (ii) lower environmental levels of Al, Cd, Co, Cr, Cu, Ni and Pb. This study identified no association between EGS cases and the environmental concentrations of Ba, Ga, Fe, Mg, Mn, P or Sr. Conclusions A number of statistically significant associations were identified between EGS cases and element concentrations in the spatially extrapolated stream sediment and soil data. This information will assist future studies on the aetiology of EGS, with further research suggested to focus on those identified significant associations with greatest biological plausibility such as reduced levels of Cu and Zn, and higher levels of K and Se. Ethical animal research: Informed client consent was obtained for the use of clinical records. Sources of funding: Part‐funded by The BGS University Funding Initiative. A.L. is funded by the Scottish Government's Rural and Environment Science and Analytical Services Division. C.E.W. is supported by The Margaret Giffen Trust. F.F. is funded by the Natural Environment Research Council (NERC). Competing interests: None.
  • Editor: Fordham: Blackwell Publishing Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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