Idioma:

Antiallergic Effect of ZCR-2060: Antihistaminic Action

Abe, Tooru ; Omata, Takeshi ; Yoshida, Kenji ; Matsumura, Toshihiro ; Ikeda, Yugo ; Segawa, Yoshihide ; Matsuda, Kazuo ; Nagai, Hiroichi

The Japanese Journal of Pharmacology, 1994, Vol.66(1), pp.87-94

Kyoto: The Japanese Pharmacological Society

Texto completo disponível

Citações Citado por

Enviar para

Título:
Antiallergic Effect of ZCR-2060: Antihistaminic Action
Autor: Abe, Tooru ; Omata, Takeshi ; Yoshida, Kenji ; Matsumura, Toshihiro ; Ikeda, Yugo ; Segawa, Yoshihide ; Matsuda, Kazuo ; Nagai, Hiroichi
Assuntos: Animals ; Antiallergic agent ; Benzoates - adverse effects ; Benzoates - pharmacology ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Dermatitis, Contact - prevention & control ; Exploratory Behavior - drug effects ; Guinea Pigs ; Histamine - pharmacology ; Histamine and antagonists. Allergy ; Histamine H1 Antagonists - adverse effects ; Histamine H1 Antagonists - pharmacology ; Histamine H1-receptor antagonist ; Hypersensitivity - drug therapy ; In Vitro Techniques ; Lung - drug effects ; Lung - metabolism ; Male ; Medical sciences ; Membranes - drug effects ; Membranes - metabolism ; Mice ; Mice, Inbred ICR ; Mice, Inbred Strains ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Non-sedative antihistamine ; Pharmacology. Drug treatments ; Piperidines - adverse effects ; Piperidines - pharmacology ; Pyrilamine - pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Sleep - drug effects ; Thiopental - pharmacology ; ZCR-2060
É parte de: The Japanese Journal of Pharmacology, 1994, Vol.66(1), pp.87-94
Descrição: The antihistaminic effect of 2-[2-[4-(diphenylmethyl)-1-piperadinyl]ethoxy] benzoic acid maleate (ZCR-2060), a newly synthesized antiallergic agent, was investigated in both in vitro and in vivo studies. ZCR-2060 clearly antagonized histamine-induced contraction of isolated guinea pig ileum and trachea. In contrast, carbachol-, BaCl2- and 5-hydroxytryptamine-induced contractions of isolated guinea pig ileum were slightly inhibited by higher concentrations of ZCR-2060.3H-Mepyramine specific binding to membranes from guinea pig lung and brain were markedly inhibited by ZCR-2060 in a concentration-dependent fashion. In the in vitro studies, the antihistaminic effect of ZCR-2060 was greater than those of cetirizine and terfenadine, but was less than that of ketotifen. In the in vivo studies, ZCR-2060 significantly inhibited the histamine-induced cutaneous reaction in rats, when administered orally 1 hr before the histamine injection. Moreover, ZCR-2060 has a long-lasting antihistaminic effect. In the in vivo studies, the antihistaminic effect of ZCR-2060 was found to be greater than that of cetirizine and terfenadine, and it was the same as that of ketotifen. Thiopental-induced sleep and spontaneous ambulatory activity in mice, however, were unaffected by ZCR-2060 at higher doses. These results indicate that ZCR-2060 has a potent, selective and long acting histamine Η1-receptor antagonistic action without causing any unwanted CNS side effect.
Editor: Kyoto: The Japanese Pharmacological Society
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Antiallergic Effect of ZCR-2060: Antihistaminic Action

Abe, Tooru ; Omata, Takeshi ; Yoshida, Kenji ; Matsumura, Toshihiro ; Ikeda, Yugo ; Segawa, Yoshihide ; Matsuda, Kazuo ; Nagai, Hiroichi

Kyoto: The Japanese Pharmacological Society

Buscando em bases de dados remotas. Favor aguardar.