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Association of sleep-wake habits in older people with changes in output of circadian pacemaker

Czeisler, C.A ; Dumont, M ; Duffy, J.F ; Steinberg, J.D ; Richardson, G.S ; Brown, E.N ; Sánchez, R ; Ríos, C.D ; Ronda, J.M

The Lancet (British edition), 1992-10, Vol.340 (8825), p.933-936 [Periódico revisado por pares]

Legacy CDMS: Elsevier Ltd

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Título:
Association of sleep-wake habits in older people with changes in output of circadian pacemaker
Autor: Czeisler, C.A ; Dumont, M ; Duffy, J.F ; Steinberg, J.D ; Richardson, G.S ; Brown, E.N ; Sánchez, R ; Ríos, C.D ; Ronda, J.M
Assuntos: Adult ; Aged ; Aged, 80 and over ; Aging - physiology ; Biological and medical sciences ; Biological clocks ; Body Temperature ; Circadian Rhythm ; Female ; General & Internal Medicine ; Geriatrics ; Humans ; Life Sciences & Biomedicine ; Life Sciences (General) ; Male ; Medical research ; Medical sciences ; Medicine, General & Internal ; Older people ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Science & Technology ; Sex Factors ; Sleep ; Sleep Deprivation - physiopathology ; Space life sciences ; Time Factors
É parte de: The Lancet (British edition), 1992-10, Vol.340 (8825), p.933-936
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Descrição: Many elderly people complain of disturbed sleep patterns but there is no evidence that the need to sleep decreases with age; it seems rather that the timing and consolidation of sleep change. We tried to find out whether there is a concurrent change in the output of the circadian pacemaker with age. The phase and amplitude of the pacemaker's output were assessed by continuous measurement of the core body temperature during 40 h of sustained wakefulness under constant behavioural and environmental conditions. 27 young men (18-31 years) were compared with 21 older people (65-85 years; 11 men, 10 women); all were healthy and without sleep complaints. The mean amplitude of the endogenous circadian temperature oscillation (ECA) was 40% greater in young men than in the older group. Older men had a lower mean temperature ECA than older women. The minimum of the endogenous phase of the circadian temperature oscillation (ECP) occurred 1 h 52 min earlier in the older than in the young group. Customary bedtimes and waketimes were also earlier in the older group, as was their daily alertness peak. There was a close correlation between habitual waketime and temperature ECP in young men, which may lose precision with age, especially among women. These findings provide evidence for systematic age-related changes in the output of the human circadian pacemaker. We suggest that these changes may underlie the common complaints of sleep disturbance among elderly people. These changes could reflect the observed age-related deterioration of the hypothalmic nuclei that drive mammalian circadian rhythms.
Editor: Legacy CDMS: Elsevier Ltd
Idioma: Inglês

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Association of sleep-wake habits in older people with changes in output of circadian pacemaker

Czeisler, C.A ; Dumont, M ; Duffy, J.F ; Steinberg, J.D ; Richardson, G.S ; Brown, E.N ; Sánchez, R ; Ríos, C.D ; Ronda, J.M

Legacy CDMS: Elsevier Ltd

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