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Association between kidney function and Framingham risk score in an admixed population of Brazil

Costa, Brunna Soares Rodrigues ; Freitas, Erika Paula Silva ; Cruz, Marina Sampaio ; Duarte, Victor Hugo Rezende ; Silva, Ananília Medeiros Gomes da ; Santos, Isabelle Cristina Clemente dos ; Santos, Jéssica Cavalcante dos ; Rezende, Adriana Augusto ; Sena-Evangelista, Karine Cavalcanti Maurício ; Silbiger, Vivian Nogueira

Brazilian Journal of Pharmaceutical Sciences, 2017-01, Vol.53 (3) [Periódico revisado por pares]

Sao Paulo: Universidade de Sao Paulo Faculdade de Ciencias

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Título:
Association between kidney function and Framingham risk score in an admixed population of Brazil
Autor: Costa, Brunna Soares Rodrigues ; Freitas, Erika Paula Silva ; Cruz, Marina Sampaio ; Duarte, Victor Hugo Rezende ; Silva, Ananília Medeiros Gomes da ; Santos, Isabelle Cristina Clemente dos ; Santos, Jéssica Cavalcante dos ; Rezende, Adriana Augusto ; Sena-Evangelista, Karine Cavalcanti Maurício ; Silbiger, Vivian Nogueira
Assuntos: Blood pressure ; Body mass index ; Cardiovascular diseases/risk factors ; Cholesterol ; Chronic kidney disease ; Collaboration ; Creatinine ; Diabetes ; Epidemiology ; Fasting ; Females ; Framingham risk score (FRS) ; Glomerular filtration rate ; Glucose ; Hypertension ; Investigations ; Kidney diseases ; Low density lipoprotein ; Males ; Mortality ; PHARMACOLOGY & PHARMACY ; Population ; Risk factors ; Smoking ; Triglycerides ; Urine
É parte de: Brazilian Journal of Pharmaceutical Sciences, 2017-01, Vol.53 (3)
Descrição: Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk development. However, the mechanisms of reduced kidney function with CVD risk are unclear. This study aimed to investigate the association between kidney function and Framingham risk score (FRS) in participants with traditional cardiovascular risk factors and normal estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m² in an admixed population of Brazil. The participants were divided into three groups according to FRS: low risk group with 0% to <10%, moderate risk group with ≥10% to 20% and high risk group with >20%. The eGFR was calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). Data from participants were collected by questionnaire, and blood and urine samples were collected to analyze biochemical markers. A total of 214 subjects aged 53±10 years old was collected. There were 77 individuals in low risk group, 59 in moderate risk group and 78 in high-risk group. Mean eGFRCKD-EPI was 89.39±15.05 mL/min/1.73 m² and 90.74±16.17 mL/min/1.73 m2 when race adjustment. The results indicated that there is an increasing the cardiovascular risk with a decreased of eGFR, conforming to a significant inverse correlation observed between eGFR and FRS with Spearman correlation (R²=-0.256, p<0.001; R²=-0.224, p=0.001, when adjusted for race). There was a statistically significant difference in eGFRCKD-EPI (p<0.001) and eGFRCKD-EPI with race adjustment (p=0.002) among risk groups. The data suggests that the reduction eGFR is associated with elevated FRS among Brazilian adults without CKD. Furthermore, the results suggest that race adjustment it’s not necessary in Brazilian population.
Editor: Sao Paulo: Universidade de Sao Paulo Faculdade de Ciencias
Idioma: Inglês;Português

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Association between kidney function and Framingham risk score in an admixed population of Brazil

Sao Paulo: Universidade de Sao Paulo Faculdade de Ciencias

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