skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

The multifaceted role of cell cycle regulators in the coordination of growth and metabolism

Huber, Katharina ; Mestres‐Arenas, Alberto ; Fajas, Lluis ; Leal‐Esteban, Lucia C.

The FEBS journal, 2021-06, Vol.288 (12), p.3813-3833 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

Texto completo disponível

Citações Citado por
  • Título:
    The multifaceted role of cell cycle regulators in the coordination of growth and metabolism
  • Autor: Huber, Katharina ; Mestres‐Arenas, Alberto ; Fajas, Lluis ; Leal‐Esteban, Lucia C.
  • Assuntos: Cell cycle ; cell cycle regulators ; Cell division ; cell growth ; Coordination ; Cyclins ; E2F protein ; endolysosomes ; Environmental conditions ; Kinases ; Metabolism ; Mitochondria ; Nutrient availability ; Regulatory subunits ; Retinoblastoma ; State‐of‐the‐Art Review ; State‐of‐the‐Art Reviews ; Transcription factors
  • É parte de: The FEBS journal, 2021-06, Vol.288 (12), p.3813-3833
  • Notas: Correction added on 15 December 2020 , after first online publication: Peer review history is not available for this article, so the peer review history statement has been removed.
    ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: This review discusses how the control of proliferation and cell division by cell cycle regulators is also involved in the metabolic adaptive responses when cells need to produce energy. We describe how cell cycle regulators are involved in the control of metabolic pathways, in cell growth and the functionality of organelles including endolysosomes and mitochondria. Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires a multi‐directional coordination between metabolism, growth, and the cell cycle regulators (consisting of the family of cyclin‐dependent kinases (CDKs), their regulatory subunits known as cyclins, CDK inhibitors, the retinoblastoma family members, and the E2F transcription factors). Deciphering the mechanisms accountable for this coordination is crucial for understanding various patho‐physiological processes. While it is well established that metabolism and growth affect cell division, this review will focus on recent observations that demonstrate how cell cycle regulators coordinate metabolism, cell cycle progression, and growth. We will discuss how the cell cycle regulators directly regulate metabolic enzymes and pathways and summarize their involvement in the endolysosomal pathway and in the functions and dynamics of mitochondria.
  • Editor: England: Blackwell Publishing Ltd
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.