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The roles of Na/Pi-II transporters in phosphate metabolism

Segawa, Hiroko ; Aranami, Fumito ; Kaneko, Ichiro ; Tomoe, Yuka ; Miyamoto, Ken-ichi

Bone (New York, N.Y.), 2009-07, Vol.45, p.S2-S7 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
The roles of Na/Pi-II transporters in phosphate metabolism
Autor: Segawa, Hiroko ; Aranami, Fumito ; Kaneko, Ichiro ; Tomoe, Yuka ; Miyamoto, Ken-ichi
Assuntos: Animals ; Bone ; Familial Hypophosphatemic Rickets - complications ; Familial Hypophosphatemic Rickets - metabolism ; Humans ; Hypercalciuria - complications ; Hypercalciuria - metabolism ; Hypophosphatemia ; Kidney ; Mutation - genetics ; Orthopedics ; Phosphates - metabolism ; Phosphoproteins - genetics ; Renal phosphate transporter ; Rickets ; SLC34 ; Sodium-Hydrogen Exchangers - genetics ; Sodium-Phosphate Cotransporter Proteins, Type II - chemistry ; Sodium-Phosphate Cotransporter Proteins, Type II - genetics ; Sodium-Phosphate Cotransporter Proteins, Type II - metabolism
É parte de: Bone (New York, N.Y.), 2009-07, Vol.45, p.S2-S7
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Descrição: Abstract The renal type II Na/Pi cotransporters, Na/Pi-IIa and Na/Pi-IIc, are expressed in the brush border membrane (BBM) of the renal proximal tubule cells. Because it has long been thought that Na/Pi-IIa alone can regulate the reabsorption of phosphate in the proximal renal tubules, Na/Pi-IIc has not been paid much attention by the renal research community. Recent studies, however, have identified Na/Pi-IIc mutations as the defective cause of hereditary hypophosphatemic rickets with hypercalciuria (HHRH). This finding indicates that Na/Pi-IIc has a rather important role in renal Pi reabsorption and bone mineralization, and that it may be a key determinant of plasma Pi concentrations in humans. Studies of Na/Pi-IIc mice indicate that Na/Pi-IIc is necessary for normal calcium homeostasis, but its role in the regulation of Pi metabolism and bone physiology may be different from that in HHRH patients. Of note, Na/Pi-IIc KO mice display abnormal vitamin D regulation without hypophosphatemia or hyperphosphaturia. Thus, Na/Pi-IIc may be involved in regulating renal vitamin D synthesis in the proximal tubular cells. The identification of proteins that interact with Na/Pi-IIc is an important area of future research. The physiologic roles of Na/Pi-IIa and Na/Pi-IIc require future elucidation.
Editor: United States: Elsevier Inc
Idioma: Inglês

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The roles of Na/Pi-II transporters in phosphate metabolism

Segawa, Hiroko ; Aranami, Fumito ; Kaneko, Ichiro ; Tomoe, Yuka ; Miyamoto, Ken-ichi

United States: Elsevier Inc

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