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Neurolysin Knockout Mice in a Diet-Induced Obesity Model

Caprioli, Bruna ; Eichler, Rosangela A. S ; Silva, Renée N. O ; Martucci, Luiz Felipe ; Reckziegel, Patricia ; Ferro, Emer S

International journal of molecular sciences, 2023-10, Vol.24 (20), p.15190 [Periódico revisado por pares]

Basel: MDPI AG

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  • Título:
    Neurolysin Knockout Mice in a Diet-Induced Obesity Model
  • Autor: Caprioli, Bruna ; Eichler, Rosangela A. S ; Silva, Renée N. O ; Martucci, Luiz Felipe ; Reckziegel, Patricia ; Ferro, Emer S
  • Assuntos: adipose tissue ; Amino acids ; Animals ; Body fat ; Carbohydrates ; Diet ; diet-induced obesity ; Energy ; Females ; Homeostasis ; Insulin ; intracellular peptides ; Metabolism ; neurolysin ; Neuropeptides ; neurotensin ; Obesity ; Peptides ; Proteases ; Proteins ; Signal transduction ; Type 2 diabetes
  • É parte de: International journal of molecular sciences, 2023-10, Vol.24 (20), p.15190
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Renée N. O. Silva is now a postdoctoral fellowship at Lawrence D. Longo MD Center for Perinatal Biology, Loma Linda University, Loma Linda, CA 92350, USA.
  • Descrição: Neurolysin oligopeptidase (E.C.3.4.24.16; Nln), a member of the zinc metallopeptidase M3 family, was first identified in rat brain synaptic membranes hydrolyzing neurotensin at the Pro-Tyr peptide bond. The previous development of C57BL6/N mice with suppression of Nln gene expression (Nln-/-), demonstrated the biological relevance of this oligopeptidase for insulin signaling and glucose uptake. Here, several metabolic parameters were investigated in Nln-/- and wild-type C57BL6/N animals (WT; n = 5–8), male and female, fed either a standard (SD) or a hypercaloric diet (HD), for seven weeks. Higher food intake and body mass gain was observed for Nln-/- animals fed HD, compared to both male and female WT control animals fed HD. Leptin gene expression was higher in Nln-/- male and female animals fed HD, compared to WT controls. Both WT and Nln-/- females fed HD showed similar gene expression increase of dipeptidyl peptidase 4 (DPP4), a peptidase related to glucagon-like peptide-1 (GLP-1) metabolism. The present data suggest that Nln participates in the physiological mechanisms related to diet-induced obesity. Further studies will be necessary to better understand the molecular mechanism responsible for the higher body mass gain observed in Nln-/- animals fed HD.
  • Editor: Basel: MDPI AG
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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