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Inner nuclear membrane localization of epidermal growth factor receptor (EGFR) in spontaneous canine model of invasive micropapillary carcinoma of the mammary gland

Rodrigues, Michele A. ; Gamba, Conrado O. ; Faria, Jerusa Araújo Quintão Arantes ; Ferreira, Ênio ; Goes, Alfredo M. ; Gomes, Dawidson A. ; Cassali, Geovanni. D.

Pathology, research and practice, 2016-04, Vol.212 (4), p.340-344 [Periódico revisado por pares]

Germany: Elsevier GmbH

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Título:
Inner nuclear membrane localization of epidermal growth factor receptor (EGFR) in spontaneous canine model of invasive micropapillary carcinoma of the mammary gland
Autor: Rodrigues, Michele A. ; Gamba, Conrado O. ; Faria, Jerusa Araújo Quintão Arantes ; Ferreira, Ênio ; Goes, Alfredo M. ; Gomes, Dawidson A. ; Cassali, Geovanni. D.
Assuntos: Animals ; Blotting, Western ; Carcinoma, Papillary - metabolism ; Carcinoma, Papillary - pathology ; Carcinoma, Papillary - veterinary ; Confocal microscopy ; Disease Models, Animal ; Dog Diseases - metabolism ; Dog Diseases - pathology ; Dogs ; ErbB Receptors - metabolism ; Female ; Fluorescent Antibody Technique ; Invasive micropapillary carcinoma ; Mammary Neoplasms, Animal - metabolism ; Mammary Neoplasms, Animal - pathology ; Microscopy, Confocal ; Nuclear EGFR ; Nuclear Envelope - metabolism ; Prognosis
É parte de: Pathology, research and practice, 2016-04, Vol.212 (4), p.340-344
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The epidermal growth factor receptor (EGFR) has been described in the nucleus of primary tumors. Accumulation of EGFR at the nucleus is linked to DNA synthesis and cell proliferation, but the pathological significance of nuclear EGFR is not completely understood. The aim of this study was to investigate the nuclear localization of EGFR in invasive micropapillary carcinoma (IMPC) that is an aggressive neoplasm of canine mammary gland. Confocal immunofluorescence of formalin and paraffin-embedded tissue was used to access the subcellular localization of EGFR. Our results demonstrated that EGFR co-localizes with the inner nuclear envelope marker, Lamin B1 in IMPC. Furthermore, EGFR was not localized within the nucleus or at the inner nuclear envelope membrane in mammary carcinoma in mixed tumor (CMT) that is associated with a better prognosis than other malignant histological types. This finding could be useful as a predictive biomarker of therapeutic response for IMPC.
Editor: Germany: Elsevier GmbH
Idioma: Inglês

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Inner nuclear membrane localization of epidermal growth factor receptor (EGFR) in spontaneous canine model of invasive micropapillary carcinoma of the mammary gland

Rodrigues, Michele A. ; Gamba, Conrado O. ; Faria, Jerusa Araújo Quintão Arantes ; Ferreira, Ênio ; Goes, Alfredo M. ; Gomes, Dawidson A. ; Cassali, Geovanni. D.

Germany: Elsevier GmbH

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