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Impulsivity across reactive, proactive and cognitive domains in Parkinson's disease on dopaminergic medication: Evidence for multiple domain impairment

Canário, Nádia ; Sousa, Mário ; Moreira, Fradique ; Duarte, Isabel Catarina ; Oliveira, Francisco ; Januário, Cristina ; Castelo-Branco, Miguel Gullo, Matthew J.

PloS one, 2019-02, Vol.14 (2), p.e0210880-e0210880 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Impulsivity across reactive, proactive and cognitive domains in Parkinson's disease on dopaminergic medication: Evidence for multiple domain impairment
Autor: Canário, Nádia ; Sousa, Mário ; Moreira, Fradique ; Duarte, Isabel Catarina ; Oliveira, Francisco ; Januário, Cristina ; Castelo-Branco, Miguel
Gullo, Matthew J.
Assuntos: Addictive behaviors ; Aged ; Behavior ; Biology and Life Sciences ; Brain research ; Care and treatment ; Cognitive ability ; Complications and side effects ; Decision making ; Diagnosis ; Disease control ; Domains ; Dopamine ; Dopamine Agents - administration & dosage ; Dopamine Agents - adverse effects ; Dopamine receptors ; Drugs ; Female ; Gambling ; Health informatics ; Hospitals ; Humans ; Impairment ; Impulse control disorders ; Impulsive behavior ; Impulsive Behavior - drug effects ; Impulsive personality ; Impulsivity ; Laboratories ; Life sciences ; Male ; Medical imaging ; Medical research ; Medicine and Health Sciences ; Middle Aged ; Motor Activity - drug effects ; Movement disorders ; Neurodegenerative diseases ; Neurology ; NMR ; Non-Randomized Controlled Trials as Topic ; Nuclear magnetic resonance ; Parkinson disease ; Parkinson Disease - drug therapy ; Parkinson Disease - physiopathology ; Parkinson's disease ; Parkinsons disease ; Patients ; Physical Sciences ; Reinforcement ; Risk factors ; Risk taking ; Social Sciences ; Strategy ; Studies ; Task Performance and Analysis
É parte de: PloS one, 2019-02, Vol.14 (2), p.e0210880-e0210880
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Impulse control disorders (ICD) may occur in Parkinson's disease (PD) although it remains to be understood if such deficits may occur even in the absence of a formal ICD diagnosis. Moreover, studies addressing simultaneously distinct neurobehavioral domains, such as cognitive, proactive and reactive motor impulsivity, are still lacking. Here, we aimed to investigate if reactive, proactive and cognitive impulsivity involving risk taking are concomitantly affected in medicated PD patients, and whether deficits were dependent on response strategies, such as speed accuracy tradeoffs, or the proportion of omission vs. commission errors. We assessed three different impulsivity domains in a sample of 21 PD patients and 13 matched controls. We found impaired impulsivity in both reactive (p = 0.042) and cognitive domains (p = 0.015) for the PD patients, irrespective of response strategy. For the latter, effect sizes were larger for the actions related with reward processing (p = 0.017, dCohen = 0.9). In the proactive impulsivity task, PD patients showed significantly increased number of omissions (p = 0.041), a response strategy which was associated with preserved number of commission errors. Moreover, the number of premature and proactive response errors were correlated with disease stage. Our findings suggest that PD ON medication is characterized compared to healthy controls by impairment across several impulsivity domains, which is moderated in the proactive domain by the response strategy.
Editor: United States: Public Library of Science
Idioma: Inglês

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Impulsivity across reactive, proactive and cognitive domains in Parkinson's disease on dopaminergic medication: Evidence for multiple domain impairment

Canário, Nádia ; Sousa, Mário ; Moreira, Fradique ; Duarte, Isabel Catarina ; Oliveira, Francisco ; Januário, Cristina ; Castelo-Branco, Miguel Gullo, Matthew J.

United States: Public Library of Science

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