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Antiviral evaluation of1,4-disubstituted-1,2,3-triazole derivativesagainst Chikungunya virus: supplementary figures

Won-Held Rabelo, Vitor ; Diniz da Silva, Veronica ; Leonisa Sanchez Nunez, Maria ; dos Santos Correa Amorim, Leonardo ; Djenne Buarque, Camilla ; J Kuhn, Richard ; Alvarez Abreu, Paula ; Christina Nunes de Palmer Paixao, Izabel

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Título:
Antiviral evaluation of1,4-disubstituted-1,2,3-triazole derivativesagainst Chikungunya virus: supplementary figures
Autor: Won-Held Rabelo, Vitor ; Diniz da Silva, Veronica ; Leonisa Sanchez Nunez, Maria ; dos Santos Correa Amorim, Leonardo ; Djenne Buarque, Camilla ; J Kuhn, Richard ; Alvarez Abreu, Paula ; Christina Nunes de Palmer Paixao, Izabel
Notas: 10.2217/fvl-2023-0142
RelationTypeNote: IsSupplementTo -- 10.2217/fvl-2023-0142
Descrição: Aim: This work aimed to investigate the antiviral activity of two 1,4-disubstituted-1,2,3-triazole derivatives(1 and 2) against Chikungunya virus (CHIKV) replication. Materials & methods: Cytotoxicity was analyzedusing colorimetric assays and the antiviral potential was evaluated using plaque assays and computationaltools. Results: Compound 2 showed antiviral activity against CHIKV 181-25 in BHK-21 and Vero cells.Also, this compound presented a higher activity against CHIKV BRA/RJ/18 in Vero cells, like compound1. Compound 2 exhibited virucidal activity and inhibited virus entry while compound 1 inhibited virusrelease. Molecular docking suggested that these derivatives inhibit nsP1 protein while compound 1 mayalso target capsid protein. Conclusion: Both compounds exhibit promising antiviral activity against CHIKVby blocking different steps of virus replication.
Editor: Taylor & Francis
Data de criação/publicação: 2023
Idioma: Inglês

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