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The evolution of experimental Trypanosoma cruzi cardiomyopathy in rabbits: further parasitological, morphological and functional studies

Figueiredo, Florêncio ; Marin-Neto, J.A. ; Rossi, Marcos A.

International journal of cardiology, 1986-03, Vol.10 (3), p.277-290 [Periódico revisado por pares]

Shannon: Elsevier Ireland Ltd

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Título:
The evolution of experimental Trypanosoma cruzi cardiomyopathy in rabbits: further parasitological, morphological and functional studies
Autor: Figueiredo, Florêncio ; Marin-Neto, J.A. ; Rossi, Marcos A.
Assuntos: Actin Cytoskeleton - ultrastructure ; Animals ; Antibodies - analysis ; Biological and medical sciences ; Cardiology. Vascular system ; Chagas Cardiomyopathy - immunology ; Chagas Cardiomyopathy - pathology ; Chagas' disease ; experimental model ; Experimental protozoal diseases and models ; Fluorescent Antibody Technique ; Heart Ventricles - pathology ; Human protozoal diseases ; Infectious diseases ; Medical sciences ; Microscopy, Electron ; Myocardial Contraction ; Myocardium - pathology ; Myofibrils - ultrastructure ; Necrosis ; Parasitic diseases ; Protozoal diseases ; Rabbits ; Tropical medicine ; Trypanosoma cruzi - immunology ; Trypanosomiasis
É parte de: International journal of cardiology, 1986-03, Vol.10 (3), p.277-290
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Young rabbits (1–2 months of age) inoculated with trypomastigote forms of the Colombia strain of Trypanosoma cruzi have been shown to develop cardiac pathological changes (together with parasitological and immunological alterations) which are very similar to those observed in the acute and chronic phases of Chagas' disease in man. The cardiac alterations in the acute phase are characterized grossly by slight cardiomegaly with dilatation of the right-sided chambers. Microscopically they are characterized by mild focal myocarditis. The chronic phase is characterized by moderate to marked cardiomegaly with hypertrophy and dilatation of both ventricular chambers. There is thinning of the apical region (apical aneurysm), particularly of the left ventricle. Focal myocarditis is seen microscopically with areas of myocytolytic necrosis, atrophic and hypertrophic myofibers, an inflammatory response predominantly composed of mononuclear cells and interstitial fibrosis. Cineventriculography in the left ventricle of rabbits during the chronic phase disclosed regional myocardial dysfunction, with typical apical systolic bulging. The pathogenesis of Chagasic cardiomyopathy is briefly discussed in the light of these findings. Our investigation has further shown that this animal model is particularly suitable for studies on the mechanisms, pathology and treatment of Chagas' heart disease.
Editor: Shannon: Elsevier Ireland Ltd
Idioma: Inglês

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The evolution of experimental Trypanosoma cruzi cardiomyopathy in rabbits: further parasitological, morphological and functional studies

Figueiredo, Florêncio ; Marin-Neto, J.A. ; Rossi, Marcos A.

Shannon: Elsevier Ireland Ltd

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