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Increased intra-subject variability of neural activity during speech production in people with autism spectrum disorder

Heller Murray, Elizabeth S. ; Segawa, Jennifer ; Karahanoglu, F. Isik ; Tocci, Catherine ; Tourville, Jason A. ; Nieto-Castanon, Alfonso ; Tager-Flusberg, Helen ; Manoach, Dara S. ; Guenther, Frank H.

Research in autism spectrum disorders, 2022-06, Vol.94, p.101955, Article 101955 [Periódico revisado por pares]

Netherlands: Elsevier Ltd

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  • Título:
    Increased intra-subject variability of neural activity during speech production in people with autism spectrum disorder
  • Autor: Heller Murray, Elizabeth S. ; Segawa, Jennifer ; Karahanoglu, F. Isik ; Tocci, Catherine ; Tourville, Jason A. ; Nieto-Castanon, Alfonso ; Tager-Flusberg, Helen ; Manoach, Dara S. ; Guenther, Frank H.
  • Assuntos: Communication ; Functional magnetic resonance imaging ; Speech ; Variability
  • É parte de: Research in autism spectrum disorders, 2022-06, Vol.94, p.101955, Article 101955
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Present address: Temple University, Department of Communication Sciences and Disorders, Weiss Hall, 1701 N. 13th Street, Philadelphia, PA, 19122
    Present address: Harvard University, Center for Brain Science, 52 Oxford St., Cambridge, MA 02138.
  • Descrição: Communication difficulties are a core deficit in many people with autism spectrum disorder (ASD). The current study evaluated neural activation in participants with ASD and neurotypical (NT) controls during a speech production task. Neural activities of participants with ASD (N = 15, M = 16.7 years, language abilities ranged from low verbal abilities to verbally fluent) and NT controls (N = 12, M = 17.1 years) was examined using functional magnetic resonance imaging with a sparse-sampling paradigm. There were no differences between the ASD and NT groups in average speech activation or inter-subject run-to-run variability in speech activation. Intra-subject run-to-run neural variability was greater in the ASD group and was positively correlated with autism severity in cortical areas associated with speech. These findings highlight the importance of understanding intra-subject neural variability in participants with ASD. •An fMRI speech production task was done with participants with ASD who ranged from low verbal abilities to verbally fluent.•There was no difference in speech activation in participants with ASD and neurotypical controls.•Participants with ASD had increased intra-subject variability in neural activity during speech compared to NT participants.•Increased intra-subject variability was associated with increased autism severity in the ASD group, measured via ADOS-CSS.
  • Editor: Netherlands: Elsevier Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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