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A study on the association between infectious burden and Alzheimer's disease

Bu, X.-L. ; Yao, X.-Q. ; Jiao, S.-S. ; Zeng, F. ; Liu, Y.-H. ; Xiang, Y. ; Liang, C.-R. ; Wang, Q.-H. ; Wang, X. ; Cao, H.-Y. ; Yi, X. ; Deng, B. ; Liu, C.-H. ; Xu, J. ; Zhang, L.-L. ; Gao, C.-Y. ; Xu, Z.-Q. ; Zhang, M. ; Wang, L. ; Tan, X.-L. ; Xu, X. ; Zhou, H.-D. ; Wang, Y.-J.

European journal of neurology, 2015-12, Vol.22 (12), p.1519-1525 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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  • Título:
    A study on the association between infectious burden and Alzheimer's disease
  • Autor: Bu, X.-L. ; Yao, X.-Q. ; Jiao, S.-S. ; Zeng, F. ; Liu, Y.-H. ; Xiang, Y. ; Liang, C.-R. ; Wang, Q.-H. ; Wang, X. ; Cao, H.-Y. ; Yi, X. ; Deng, B. ; Liu, C.-H. ; Xu, J. ; Zhang, L.-L. ; Gao, C.-Y. ; Xu, Z.-Q. ; Zhang, M. ; Wang, L. ; Tan, X.-L. ; Xu, X. ; Zhou, H.-D. ; Wang, Y.-J.
  • Assuntos: Aged ; Aged, 80 and over ; Alzheimer Disease - blood ; Alzheimer Disease - etiology ; Alzheimer's disease ; Amyloid beta-Peptides - blood ; Bacterial Infections - blood ; beta-amyloid ; Borrelia burgdorferi ; Case-Control Studies ; case−control study ; Chlamydophila pneumoniae ; Cytomegalovirus ; Female ; Helicobacter pylori ; Herpes simplex virus 1 ; Herpesviridae Infections - blood ; Humans ; infections ; Male ; Middle Aged ; risk factors
  • É parte de: European journal of neurology, 2015-12, Vol.22 (12), p.1519-1525
  • Notas: Table S1. The correlation of cognitive status with infectious burdena.
    Army Health Care Project - No. 13BJZ31
    ArticleID:ENE12477
    Natural Science Foundation Project of CQCSTC - No. CSTC2010BA5004
    istex:BDB13CBF3EE879E4CA2F71FA4DABFF5DB2842E58
    National Natural Science Foundation of China - No. 81270423
    ark:/67375/WNG-XCDKK3LH-K
    1503
    Videocasts of this article are available in: English
    http://player.polyv.net/videos/player.swf?vid=f6ee5715d9808c7a481b7ae727da00dd_f
    See editorial by J. M. Schott on page
    Mandarin
    http://player.polyv.net/videos/f6ee5715d98ae743a9b0509d0900c91f_f.swf
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Background and purpose Previous studies suggested that the overall burden of prior infections contributes to cardiovascular diseases and stroke. In the present study, the association between infectious burden (IB) and Alzheimer's disease (AD) was examined. Methods Antibody titers to common infectious pathogens including cytomegalovirus (CMV), herpes simplex virus type 1 (HSV‐1), Borrelia burgdorferi, Chlamydophila pneumoniae and Helicobacter pylori were measured by enzyme‐linked immunosorbent assay in 128 AD patients and 135 healthy controls. IB was defined as a composite serological measure of exposure to these common pathogens. Results Seropositivities toward zero−two, three and four−five of these pathogens were found in 44%, 40% and 16% of healthy controls but in 20%, 44% and 36% of AD patients, respectively. IB, bacterial burden and viral burden were independently associated with AD after adjusting for age, gender, education, APOE genotype and various comorbidities. Mini‐Mental State Examination scores were negatively correlated with IB in all cases. Serum beta‐amyloid protein (Aβ) levels (i.e. Aβ40, Aβ42 and total Aβ) and inflammatory cytokines (i.e. interferon‐γ, tumor necrosis factor α, interleukin‐1β and interleukin‐6) in individuals exposed to four−five infectious pathogens were significantly higher than those exposed to zero−two or three pathogens. Conclusions IB consisting of CMV, HSV‐1, B. burgdorferi, C. pneumoniae and H. pylori is associated with AD. This study supports the role of infection/inflammation in the etiopathogenesis of AD. Click here to view the accompanying paper in this issue. Videocasts of this article are available in: English: http://player.polyv.net/videos/player.swf?vid=f6ee5715d9808c7a481b7ae727da00dd_f Mandarin: http://player.polyv.net/videos/f6ee5715d98ae743a9b0509d0900c91f_f.swf
  • Editor: England: Blackwell Publishing Ltd
  • Idioma: Inglês
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