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Influence of periodontal therapy on C-reactive protein level: a systematic review and meta-analysis

Freitas, Camila Oliveira Teixeira De; Gomes-Filho, Isaac Suzart; Naves, Roberta Catapano; Nogueira Filho, Getúlio Da Rocha; Cruz, Simone Seixas Da; Santos, Carlos Antonio De Souza Teles; Dunningham, Leonardo; Miranda, Lituânia Fialho De; Barbosa, Mônica Dourado Da Silva

Journal of Applied Oral Science; v. 20 n. 1 (2012); 1-8

Universidade de São Paulo. Faculdade de Odontologia de Bauru 2012-02-01

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  • Título:
    Influence of periodontal therapy on C-reactive protein level: a systematic review and meta-analysis
  • Autor: Freitas, Camila Oliveira Teixeira De; Gomes-Filho, Isaac Suzart; Naves, Roberta Catapano; Nogueira Filho, Getúlio Da Rocha; Cruz, Simone Seixas Da; Santos, Carlos Antonio De Souza Teles; Dunningham, Leonardo; Miranda, Lituânia Fialho De; Barbosa, Mônica Dourado Da Silva
  • Assuntos: Meta-Analysis; Intervention Studies; Periodontitis; Periodontal Diseases
  • É parte de: Journal of Applied Oral Science; v. 20 n. 1 (2012); 1-8
  • Descrição: The influence of oral infections, especially periodontal disease, on systemic diseases has been extensively discussed in the literature. Because periodontal disease is a persistent infection, it promotes an inflammatory response. C-reactive protein is a marker for inflammatory reactions that is frequently studied, since elevated levels of this protein are related to coronary events. OBJECTIVE: The aim of this study was to investigate the effect of periodontal therapy on reducing the serum levels of C-reactive protein, by means of a systematic review of the literature and meta-analysis. MATERIAL AND METHODS: A systematic review of the English-language literature was conducted in the PUBMED-MEDLINE database, using the key words "periodontal disease", "C-reactive protein", "periodontal therapy" and "periodontal treatment", in accordance with the terms for Medical Subject Headings (MeSH), to evaluate the effect of periodontal therapy on C-reactive protein levels. A qualitative analysis of studies of randomized clinical trial design was performed using CONSORT, with subsequent meta-analysis. RESULTS: The literature search initially retrieved 46 potentially relevant studies available in the databases. From these, in accordance with the inclusion criteria, only 11 were selected, of which only 4 fulfilled the criteria of randomized clinical trial design. According to CONSORT, the studies evaluated generally presented good quality with regard to the criteria analyzed. Through meta-analysis, the reduction in mean levels of C-reactive protein (-0.231; p=0.000) after introducing periodontal treatment was estimated. The result was statistically significant, without evidence of heterogeneity between the studies (p=0.311). CONCLUSIONS: The findings indicated that non-surgical periodontal treatment had a positive effect with regard to reduction of the serum levels of C-reactive protein.
  • Títulos relacionados: https://www.revistas.usp.br/jaos/article/view/3977/4667
  • Editor: Universidade de São Paulo. Faculdade de Odontologia de Bauru
  • Data de criação/publicação: 2012-02-01
  • Formato: Adobe PDF
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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