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An advanced junction concept in pediatric craniospinal irradiation by proton pencil beam scanning

Fellin, Francesco ; Fracchiolla, Francesco ; Rombi, Barbara ; Lipparini, Mirko ; Vennarini, Sabina ; Farace, Paolo

Physica medica, 2019-04, Vol.60, p.168-173 [Periódico revisado por pares]

Italy: Elsevier Ltd

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  • Título:
    An advanced junction concept in pediatric craniospinal irradiation by proton pencil beam scanning
  • Autor: Fellin, Francesco ; Fracchiolla, Francesco ; Rombi, Barbara ; Lipparini, Mirko ; Vennarini, Sabina ; Farace, Paolo
  • Assuntos: Child ; Craniospinal irradiation ; Craniospinal Irradiation - methods ; Field junction ; Humans ; Proton therapy ; Proton Therapy - methods ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted
  • É parte de: Physica medica, 2019-04, Vol.60, p.168-173
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: •Proton therapy is an emerging modality for CSI in pediatric patients.•Whole brain irradiation is delivered by opposed lateral beams.•Lateral-beam size is limited by the shoulders, increasing the number of isocenters.•An advanced junction approach allowed to fully exploit the maximal field size.•This approach can reduce the number of isocenters and thus the treatment time. To present an advanced junction concept in craniospinal irradiation (CSI) by proton pencil beam scanning (PBS). In PBS CSI, whole brain irradiation (WBI) is commonly delivered by opposed lateral-beams, whereas spine irradiation is delivered by posterior entrances. Since lateral-beams would cross a large portion of the patient at the shoulder level, the junction between WBI and spine irradiation cannot extend below that level, thus the size of the lateral-beams needs to be limited and the number of required isocenters can increase. To overcome such limitation, a pseudo-junction was introduced below the posterior fossa, to turn in this region the WBI beam arrangement to a single posterior beam pointed at the same isocenter, that was matched to the posterior spinal beam more caudally, below shoulder level, in the true-junction. After assessing robustness of the technique to range and setup uncertainties, twenty-three treated patients were reviewed to estimate the percentage that might benefit of being treated by two instead of three isocenters. Target coverage at the junction levels resulted robust, with D95% > 95% on pseudo-junction and D95% > 90% on the true-junction. By the advanced junction concept, 91% of patients might by treated with only two isocenters, whereas, by the conventional method, 83% of patients required three isocenters. With the presented junction concept the number of isocenters can be reduced, with a consequent relevant reduction of treatment time, which is particularly valuable in the management of pediatric patients under anesthesia.
  • Editor: Italy: Elsevier Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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