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Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study

Taporoski, Tâmara P ; Negrão, André B ; Horimoto, Andréa R V R ; Duarte, Nubia E ; Alvim, Rafael O ; de Oliveira, Camila M ; Krieger, José E ; Schantz, Malcolm von ; Vallada, Homero ; Pereira, Alexandre C Domschke, Katharina

PloS one, 2015-12, Vol.10 (12), p.e0144255-e0144255 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study
Autor: Taporoski, Tâmara P ; Negrão, André B ; Horimoto, Andréa R V R ; Duarte, Nubia E ; Alvim, Rafael O ; de Oliveira, Camila M ; Krieger, José E ; Schantz, Malcolm von ; Vallada, Homero ; Pereira, Alexandre C
Domschke, Katharina
Assuntos: Adult ; Age ; Anxieties ; Anxiety ; Anxiety - epidemiology ; Anxiety - genetics ; Behavior disorders ; Bivariate analysis ; Brazil - epidemiology ; Cardiology ; Care and treatment ; Cohort Studies ; Covariance ; Depression - epidemiology ; Depression - genetics ; Diagnosis ; Estimates ; Family Relations ; Female ; Genetic diversity ; Genetic factors ; Genetic Predisposition to Disease ; Genetic variance ; Genetics ; Genome-wide association studies ; Genome-Wide Association Study ; Genomes ; Heart ; Heart diseases ; Heritability ; Hospitals ; Humans ; Laboratories ; Male ; Medical schools ; Medicin och hälsovetenskap ; Mental depression ; Middle Aged ; Pedigree ; Phenotype ; Physiology ; Population ; Psychiatry ; Risk factors ; Sex Factors ; Social Environment ; Studies ; Variance analysis
É parte de: PloS one, 2015-12, Vol.10 (12), p.e0144255-e0144255
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: ACP JEK CMO ABN. Performed the experiments: ACP JEK CMO. Analyzed the data: TPT ACP HV MvS NED ARVRH ABN. Contributed reagents/materials/analysis tools: ACP NED ARVRH. Wrote the paper: TPT ACP HV MvS ROA NED ARVRH ABN.
Descrição: To investigate the phenotypic and genetic overlap between anxiety and depression symptoms in an admixed population from extended family pedigrees. Participants (n = 1,375) were recruited from a cohort of 93 families (mean age±SD 42±16.3, 57% female) in the rural town of Baependi, Brazil. The Hospital Anxiety and Depression Scale (HADS) was used to assess depression and anxiety symptoms. Heritability estimates were obtained by an adjusted variance component model. Bivariate analyses were performed to obtain the partition of the covariance of anxiety and depression into genetic and environmental components, and to calculate the genetic contribution modulating both sets of symptoms. Anxiety and depression scores were 7.49±4.01 and 5.70±3.82, respectively. Mean scores were affected by age and were significantly higher in women. Heritability for depression and anxiety, corrected for age and sex, were 0.30 and 0.32, respectively. Significant genetic correlations (ρg = 0.81) were found between anxiety and depression scores; thus, nearly 66% of the total genetic variance in one set of symptoms was shared with the other set. Our results provided strong evidence for a genetic overlap between anxiety and depression symptoms, which has relevance for our understanding of the biological basis of these constructs and could be exploited in genome-wide association studies.
Editor: United States: Public Library of Science
Idioma: Inglês

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Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study

Taporoski, Tâmara P ; Negrão, André B ; Horimoto, Andréa R V R ; Duarte, Nubia E ; Alvim, Rafael O ; de Oliveira, Camila M ; Krieger, José E ; Schantz, Malcolm von ; Vallada, Homero ; Pereira, Alexandre C Domschke, Katharina

United States: Public Library of Science

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