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Origin, fate and dynamics of macrophages at central nervous system interfaces

Goldmann, Tobias ; Wieghofer, Peter ; Jordão, Marta Joana Costa ; Prutek, Fabiola ; Hagemeyer, Nora ; Frenzel, Kathrin ; Amann, Lukas ; Staszewski, Ori ; Kierdorf, Katrin ; Krueger, Martin ; Locatelli, Giuseppe ; Hochgerner, Hannah ; Zeiser, Robert ; Epelman, Slava ; Geissmann, Frederic ; Priller, Josef ; Rossi, Fabio M V ; Bechmann, Ingo ; Kerschensteiner, Martin ; Linnarsson, Sten ; Jung, Steffen ; Prinz, Marco

Nature immunology, 2016-07, Vol.17 (7), p.797-805 [Periódico revisado por pares]

United States: Nature Publishing Group

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Título:
Origin, fate and dynamics of macrophages at central nervous system interfaces
Autor: Goldmann, Tobias ; Wieghofer, Peter ; Jordão, Marta Joana Costa ; Prutek, Fabiola ; Hagemeyer, Nora ; Frenzel, Kathrin ; Amann, Lukas ; Staszewski, Ori ; Kierdorf, Katrin ; Krueger, Martin ; Locatelli, Giuseppe ; Hochgerner, Hannah ; Zeiser, Robert ; Epelman, Slava ; Geissmann, Frederic ; Priller, Josef ; Rossi, Fabio M V ; Bechmann, Ingo ; Kerschensteiner, Martin ; Linnarsson, Sten ; Jung, Steffen ; Prinz, Marco
Assuntos: Analysis ; Animals ; Brain mapping ; Cell Differentiation ; Cells, Cultured ; Central nervous system ; Central Nervous System - immunology ; Choroid plexus ; Embryogenesis ; Embryonic development ; Genetic aspects ; Genetic transcription ; Health aspects ; Hematopoietic Stem Cells - physiology ; Hemopoiesis ; Immune response ; Interfaces ; Life span ; Macrophages ; Macrophages - physiology ; Medicin och hälsovetenskap ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Microglia ; Microglia - physiology ; Microscopy, Fluorescence ; Monocytes ; Monocytes - immunology ; Nervous system ; Observations ; Parabiosis ; Properties ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins - metabolism ; PU.1 protein ; Risk factors ; Trans-Activators - genetics ; Trans-Activators - metabolism ; Transcription factors ; Yolk sac
É parte de: Nature immunology, 2016-07, Vol.17 (7), p.797-805
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SourceType-Scholarly Journals-1
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Descrição: Perivascular, subdural meningeal and choroid plexus macrophages are non-parenchymal macrophages that mediate immune responses at brain boundaries. Although the origin of parenchymal microglia has recently been elucidated, much less is known about the precursors, the underlying transcriptional program and the dynamics of the other macrophages in the central nervous system (CNS). It was assumed that they have a high turnover from blood-borne monocytes. However, using parabiosis and fate-mapping approaches in mice, we found that CNS macrophages arose from hematopoietic precursors during embryonic development and established stable populations, with the notable exception of choroid plexus macrophages, which had dual origins and a shorter life span. The generation of CNS macrophages relied on the transcription factor PU.1, whereas the MYB, BATF3 and NR4A1 transcription factors were not required.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Origin, fate and dynamics of macrophages at central nervous system interfaces

United States: Nature Publishing Group

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