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Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy

Poff, A M ; Ward, N ; Seyfried, T N ; Arnold, P ; D'Agostino, D P Chandra, Dhyan

PloS one, 2015-06, Vol.10 (6), p.e0127407 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy
Autor: Poff, A M ; Ward, N ; Seyfried, T N ; Arnold, P ; D'Agostino, D P
Chandra, Dhyan
Assuntos: Angiogenesis ; Animals ; Biomedical research ; Brain cancer ; Cancer ; Cancer metastasis ; Cancer therapies ; Carbohydrates ; Cell culture ; Cell proliferation ; Dextrose ; Diet ; Diet, Ketogenic ; Dietary supplements ; Fermentation ; Glucose ; Growth rate ; Health aspects ; High fat diet ; Hyperbaric oxygen therapy ; Hyperbaric Oxygenation ; Hypoxia ; Ketogenesis ; Ketones ; Ketones - administration & dosage ; Laboratories ; Low carbohydrate diet ; Medical prognosis ; Metabolism ; Metastases ; Metastasis ; Mice ; Neoplasm Metastasis - therapy ; Neoplasms, Experimental - pathology ; Nutrition research ; Oxygen ; Oxygen therapy ; Pharmacology ; Phenotypes ; Physiology ; Researchers ; Supplementation ; Therapy ; Tumors ; Viability
É parte de: PloS one, 2015-06, Vol.10 (6), p.e0127407
Notas: Competing Interests: Patent 12B152PRWO; University of South Florida; D. P. D’Agostino, A. Poff, P. Arnold, “Targeting cancer with metabolic therapy and hyperbaric oxygen." P. Arnold (Savind Inc.) has received financial support (ONR N000140910244) from D. D’Agostino (USF) to synthesize ketone esters. The remaining authors have no conflicts of interest. Author (P. Arnold) affiliations with Savind Inc. and funding support from Scivation, Inc. does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.
Conceived and designed the experiments: AMP NW TNS PA DPD. Performed the experiments: AMP NW. Analyzed the data: AMP NW TNS DPD. Contributed reagents/materials/analysis tools: TNS PA DPD. Wrote the paper: AMP NW TNS DPD.
Descrição: The Warburg effect and tumor hypoxia underlie a unique cancer metabolic phenotype characterized by glucose dependency and aerobic fermentation. We previously showed that two non-toxic metabolic therapies - the ketogenic diet with concurrent hyperbaric oxygen (KD+HBOT) and dietary ketone supplementation - could increase survival time in the VM-M3 mouse model of metastatic cancer. We hypothesized that combining these therapies could provide an even greater therapeutic benefit in this model. Mice receiving the combination therapy demonstrated a marked reduction in tumor growth rate and metastatic spread, and lived twice as long as control animals. To further understand the effects of these metabolic therapies, we characterized the effects of high glucose (control), low glucose (LG), ketone supplementation (βHB), hyperbaric oxygen (HBOT), or combination therapy (LG+βHB+HBOT) on VM-M3 cells. Individually and combined, these metabolic therapies significantly decreased VM-M3 cell proliferation and viability. HBOT, alone or in combination with LG and βHB, increased ROS production in VM-M3 cells. This study strongly supports further investigation into this metabolic therapy as a potential non-toxic treatment for late-stage metastatic cancers.
Editor: United States: Public Library of Science
Idioma: Inglês

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Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy

Poff, A M ; Ward, N ; Seyfried, T N ; Arnold, P ; D'Agostino, D P Chandra, Dhyan

United States: Public Library of Science

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