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Modulation of intracellular iron levels by oxidative stress implicates a novel role for iron in signal transduction

Deb, Suman ; Johnson, Erin E ; Robalinho-Teixeira, Raquel L ; Wessling-Resnick, Marianne

Biometals, 2009-10, Vol.22 (5), p.855-862 [Periódico revisado por pares]

Dordrecht: Dordrecht : Springer Netherlands

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Título:
Modulation of intracellular iron levels by oxidative stress implicates a novel role for iron in signal transduction
Autor: Deb, Suman ; Johnson, Erin E ; Robalinho-Teixeira, Raquel L ; Wessling-Resnick, Marianne
Assuntos: Apoptosis - drug effects ; Biochemistry ; Biomedical and Life Sciences ; Blotting, Western ; Cell Biology ; HeLa Cells ; Humans ; Iron ; Iron - metabolism ; Life Sciences ; MAP Kinase Kinase 4 - metabolism ; Medicine/Public Health ; Microbiology ; Naphthoquinones - pharmacology ; Oxidation ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; p38 Mitogen-Activated Protein Kinases - metabolism ; Pharmacology/Toxicology ; Phosphorylation - drug effects ; Plant Physiology ; Signal transduction ; Signal Transduction - physiology ; Vitamin K 3 - pharmacology ; Vitamins - pharmacology
É parte de: Biometals, 2009-10, Vol.22 (5), p.855-862
Notas: http://dx.doi.org/10.1007/s10534-009-9214-7
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Descrição: Reactive oxygen species (ROS) display cytotoxicity that can be exacerbated by iron. Paradoxically, HeLa cells treated with the ROS-generators menadione and 2,3-dimethoxy-1,4-naphthoquinone display increased free labile iron. HeLa cells exposed to ROS undergo apoptosis but iron chelation limits the extent of cell death suggesting the rise in intracellular iron plays a signaling role in this pathway. This idea is supported by the fact that iron chelation also alters the pattern of ROS-induced phosphorylation of stress-activated protein kinases SAPK/JNK and p38 MAPK. Thus, ROS-induced increases in cellular free iron contribute to signaling events triggered during oxidative stress response.
Editor: Dordrecht: Dordrecht : Springer Netherlands
Idioma: Inglês;Holandês

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Modulation of intracellular iron levels by oxidative stress implicates a novel role for iron in signal transduction

Deb, Suman ; Johnson, Erin E ; Robalinho-Teixeira, Raquel L ; Wessling-Resnick, Marianne

Dordrecht: Dordrecht : Springer Netherlands

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