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Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene

Oliveira, Carla R. P. ; Salvatori, Roberto ; Nóbrega, Luciana M. A. ; Carvalho, Erick O. M. ; Menezes, Menilson ; Farias, Catarine T. ; Britto, Allan V. O. ; Pereira, Rossana M. C. ; Aguiar-Oliveira, Manuel H.

Clinical endocrinology (Oxford), 2008-07, Vol.69 (1), p.153-158 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene
Autor: Oliveira, Carla R. P. ; Salvatori, Roberto ; Nóbrega, Luciana M. A. ; Carvalho, Erick O. M. ; Menezes, Menilson ; Farias, Catarine T. ; Britto, Allan V. O. ; Pereira, Rossana M. C. ; Aguiar-Oliveira, Manuel H.
Assuntos: Abdomen ; Adult ; Biological and medical sciences ; Body Height - genetics ; Body Mass Index ; Case-Control Studies ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Growth Disorders - congenital ; Growth Disorders - genetics ; Growth Disorders - pathology ; Homozygote ; Hormone Replacement Therapy ; Human Growth Hormone - deficiency ; Human Growth Hormone - therapeutic use ; Humans ; Male ; Medical sciences ; Middle Aged ; Mutation - physiology ; Organ Size - drug effects ; Organ Size - genetics ; Receptors, Neuropeptide - genetics ; Receptors, Pituitary Hormone-Regulating Hormone - genetics ; Vertebrates: endocrinology
É parte de: Clinical endocrinology (Oxford), 2008-07, Vol.69 (1), p.153-158
Notas: istex:3725B1D472ACD66CBB3F0EB0ADBC1608040FEF04
ark:/67375/WNG-67HPQ4KJ-0
ArticleID:CEN3148
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Summary Objective To assess the sizes of intra‐abdominal organs of adult subjects with untreated severe congenital isolated GH deficiency (IGHD) due to lack of functional GHRH receptor (GHRH‐R), and to verify whether there is proportionality between size of organ and adult stature and body surface area (BSA). Subjects and methods By using ultrasound, we studied the sizes (absolute and corrected by height, weight and BSA) of the intra‐abdominal organs of 18 adult subjects with IGHD (eight females, IGHD group) who have never received GH replacement therapy. They were all homozygous for the same null mutation (IVS1 + 1G → A) in the GHRH receptor gene (GHRH‐R). They were compared with normal controls from the same region. Results After correction for BSA, subjects lacking a functional GHRH‐R have normal prostate and ovaries size, small spleen and uterus, and large liver, pancreas and kidney. Conclusions Size of individual abdominal organs is influenced in different ways by severe and congenital lack of GH due to a GHRH‐R mutation.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene

Oliveira, Carla R. P. ; Salvatori, Roberto ; Nóbrega, Luciana M. A. ; Carvalho, Erick O. M. ; Menezes, Menilson ; Farias, Catarine T. ; Britto, Allan V. O. ; Pereira, Rossana M. C. ; Aguiar-Oliveira, Manuel H.

Oxford, UK: Blackwell Publishing Ltd

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