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Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces

Song, Yang ; Shimanovich, Ulyana ; Michaels, Thomas C T ; Ma, Qingming ; Li, Jingmei ; Knowles, Tuomas P J ; Shum, Ho Cheung

Nature communications, 2016-10, Vol.7 (1), p.12934-8, Article 12934 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces
Autor: Song, Yang ; Shimanovich, Ulyana ; Michaels, Thomas C T ; Ma, Qingming ; Li, Jingmei ; Knowles, Tuomas P J ; Shum, Ho Cheung
Assuntos: Amyloid - chemistry ; Animals ; Chickens ; Emulsions - chemistry ; Muramidase - chemistry ; Muramidase - metabolism ; Muramidase - ultrastructure ; Nanofibers - chemistry ; Nanofibers - ultrastructure ; Polyethylene Glycols - chemistry ; Protein Aggregates ; Surface Properties ; Water - chemistry
É parte de: Nature communications, 2016-10, Vol.7 (1), p.12934-8, Article 12934
Notas: These authors contributed equally to this work
Descrição: All-aqueous emulsions exploit spontaneous liquid-liquid separation and due to their water-based nature are particular advantageous for the biocompatible storage and processing of biomacromolecules. However, the ultralow interfacial tensions characteristic of all-aqueous interfaces represent an inherent limitation to the use of thermally adsorbed particles to achieve emulsion stability. Here, we use protein nanofibrils to generate colloidosome-like two-dimensional crosslinked networks of nanostructures templated by all-aqueous emulsions, which we term fibrillosomes. We show that this approach not only allows us to operate below the thermal limit at ultra-low surface tensions but also yields structures that are stable even in the complete absence of an interface. Moreover, we show that the growth and multilayer deposition of fibrils allows us to control the thickness of the capsule shells. These results open up the possibility of stabilizing aqueous two-phase systems using natural proteins, and creating self-standing protein capsules without the requirement for three-phase emulsions or water/oil interfaces.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces

Song, Yang ; Shimanovich, Ulyana ; Michaels, Thomas C T ; Ma, Qingming ; Li, Jingmei ; Knowles, Tuomas P J ; Shum, Ho Cheung

England: Nature Publishing Group

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