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Neuronal ensemble-specific DNA methylation strengthens engram stability

Gulmez Karaca, Kubra ; Kupke, Janina ; Brito, David V C ; Zeuch, Benjamin ; Thome, Christian ; Weichenhan, Dieter ; Lutsik, Pavlo ; Plass, Christoph ; Oliveira, Ana M M

Nature communications, 2020-01, Vol.11 (1), p.639-639, Article 639 [Periódico revisado por pares]

England: Nature Publishing Group

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Neuronal ensemble-specific DNA methylation strengthens engram stability
Autor: Gulmez Karaca, Kubra ; Kupke, Janina ; Brito, David V C ; Zeuch, Benjamin ; Thome, Christian ; Weichenhan, Dieter ; Lutsik, Pavlo ; Plass, Christoph ; Oliveira, Ana M M
Assuntos: Activation ; Animals ; Cognitive ability ; Consolidation ; Dentate gyrus ; Dentate Gyrus - enzymology ; Dentate Gyrus - metabolism ; Deoxyribonucleic acid ; DNA ; DNA (Cytosine-5-)-Methyltransferases - genetics ; DNA (Cytosine-5-)-Methyltransferases - metabolism ; DNA Methylation ; DNA methyltransferase ; Fear ; Fear conditioning ; Learning ; Male ; Memory ; Memory Consolidation ; Mice ; Mice, Inbred C57BL ; Molecular modelling ; Neurons ; Neurons - enzymology ; Neurons - metabolism ; Retrieval ; Stability ; Synaptic plasticity
É parte de: Nature communications, 2020-01, Vol.11 (1), p.639-639, Article 639
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SourceType-Scholarly Journals-1
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Descrição: Memories are encoded by memory traces or engrams, represented within subsets of neurons that are synchronously activated during learning. However, the molecular mechanisms that drive engram stabilization during consolidation and consequently ensure its reactivation by memory recall are not fully understood. In this study we manipulate, during memory consolidation, the levels of the de novo DNA methyltransferase 3a2 (Dnmt3a2) selectively within dentate gyrus neurons activated by fear conditioning. We found that Dnmt3a2 upregulation enhances memory performance in mice and improves the fidelity of reconstitution of the original neuronal ensemble upon memory retrieval. Moreover, similar manipulation in a sparse, non-engram subset of neurons does not bias engram allocation or modulate memory strength. We further show that neuronal Dnmt3a2 overexpression changes the DNA methylation profile of synaptic plasticity-related genes. Our data implicates DNA methylation selectively within neuronal ensembles as a mechanism of stabilizing engrams during consolidation that supports successful memory retrieval.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Neuronal ensemble-specific DNA methylation strengthens engram stability

Gulmez Karaca, Kubra ; Kupke, Janina ; Brito, David V C ; Zeuch, Benjamin ; Thome, Christian ; Weichenhan, Dieter ; Lutsik, Pavlo ; Plass, Christoph ; Oliveira, Ana M M

England: Nature Publishing Group

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