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Circulating Antibodies against Epstein-Barr Virus (EBV) and p53 in EBV-Positive and -Negative Gastric Cancer

Camargo, M Constanza ; Kim, Kyoung-Mee ; Matsuo, Keitaro ; Torres, Javier ; Liao, Linda M ; Morgan, Douglas ; Michel, Angelika ; Waterboer, Tim ; Song, Minkyo ; Gulley, Margaret L ; Dominguez, Ricardo L ; Yatabe, Yasushi ; Kim, Sung ; Cortes-Martinez, Gustavo ; Lissowska, Jolanta ; Zabaleta, Jovanny ; Pawlita, Michael ; Rabkin, Charles S

Cancer epidemiology, biomarkers & prevention, 2020-02, Vol.29 (2), p.414-419 [Periódico revisado por pares]

United States

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Título:
Circulating Antibodies against Epstein-Barr Virus (EBV) and p53 in EBV-Positive and -Negative Gastric Cancer
Autor: Camargo, M Constanza ; Kim, Kyoung-Mee ; Matsuo, Keitaro ; Torres, Javier ; Liao, Linda M ; Morgan, Douglas ; Michel, Angelika ; Waterboer, Tim ; Song, Minkyo ; Gulley, Margaret L ; Dominguez, Ricardo L ; Yatabe, Yasushi ; Kim, Sung ; Cortes-Martinez, Gustavo ; Lissowska, Jolanta ; Zabaleta, Jovanny ; Pawlita, Michael ; Rabkin, Charles S
Assuntos: Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Capsid - immunology ; Carcinogenesis - immunology ; Epstein-Barr Virus Infections - blood ; Epstein-Barr Virus Infections - diagnosis ; Epstein-Barr Virus Infections - immunology ; Epstein-Barr Virus Infections - virology ; Epstein-Barr Virus Nuclear Antigens - immunology ; Female ; Herpesvirus 4, Human - immunology ; Herpesvirus 4, Human - isolation & purification ; Humans ; Male ; Middle Aged ; Serologic Tests ; Stomach Neoplasms - blood ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - immunology ; Stomach Neoplasms - virology ; Tumor Suppressor Protein p53 - immunology ; Virus Activation - immunology
É parte de: Cancer epidemiology, biomarkers & prevention, 2020-02, Vol.29 (2), p.414-419
Notas: Authors’ Contributions
Study concept and design: MCC, CSR
Drafting of the manuscript: MCC, CSR
Acquisition of data: KMK, KM, JT, LML, DRM, AM, TW, MLG, RLD, YY, SK, GFC-M, JL, JZ, MP
Analysis and interpretation of data: MCC, AM, TW, MS, MP, CSR
Statistical analysis: MCC, AM, TW, MP, CSR
Study supervision: MP, CSR
Critical revision of the manuscript for important intellectual content: All authors
Obtained funding: CSR
Descrição: Epstein-Barr virus (EBV)-positive gastric cancers have clinicopathologic differences from EBV-negative tumors and lack mutation. Serologic profiles may inform viral contribution to carcinogenesis. We compared humoral responses of EBV-positive ( = 67) and EBV-negative ( = 137) patients with gastric cancer from the International EBV-Gastric Cancer Consortium. Serum antibodies against four EBV proteins, nuclear (EBNA), viral capsid (VCA), early-diffuse (EA-D), and Zta replication activator (ZEBRA), and to p53 were assessed by multiplex assays. OR of antibody level tertiles (T1-T3) were adjusted by logistic regression. We also conducted a meta-analysis of reported anti-p53 seropositivity in gastric cancer. Consistent with EBV's ubiquity, 99% of patients were seropositive for anti-EBNA and 98% for anti-VCA, without difference by tumor EBV status. Seropositivity varied between patients with EBV-positive and EBV-negative tumors for anti-EA-D (97% vs. 67%, respectively, < 0.001) and anti-ZEBRA (97% vs. 85%, respectively, = 0.009). Adjusted ORs (vs. T1) for patients with EBV-positive versus EBV-negative tumors were significantly elevated for higher antibodies against EBNA (2.6 for T2 and 13 for T3), VCA (1.8 for T2 and 2.4 for T3), EA-D (6.0 for T2 and 44 for T3), and ZEBRA (4.6 for T2 and 12 for T3). Antibodies to p53 were inversely associated with EBV positivity (3% vs. 15%; adjusted OR = 0.16, = 0.021). Anti-p53 prevalence from the literature was 15%. These serologic patterns suggest viral reactivation in EBV-positive cancers and identify variation of p53 seropositivity by subtype. Anti-EBV and anti-p53 antibodies are differentially associated with tumor EBV positivity. Serology may identify EBV-positive gastric cancer for targeted therapies.
Editor: United States
Idioma: Inglês

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Circulating Antibodies against Epstein-Barr Virus (EBV) and p53 in EBV-Positive and -Negative Gastric Cancer

United States

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