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Pre-clinical left ventricular myocardial remodeling in patients with Friedreich's ataxia: A cardiac MRI study

Takazaki, Karen A G ; Quinaglia, Thiago ; Venancio, Thiago D ; Martinez, Alberto R M ; Shah, Ravi V ; Neilan, Tomas G ; Jerosch-Herold, Michael ; Coelho-Filho, Otávio R ; França, Jr, Marcondes C Jefferies, John Lynn

PloS one, 2021-03, Vol.16 (3), p.e0246633-e0246633 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Pre-clinical left ventricular myocardial remodeling in patients with Friedreich's ataxia: A cardiac MRI study
Autor: Takazaki, Karen A G ; Quinaglia, Thiago ; Venancio, Thiago D ; Martinez, Alberto R M ; Shah, Ravi V ; Neilan, Tomas G ; Jerosch-Herold, Michael ; Coelho-Filho, Otávio R ; França, Jr, Marcondes C
Jefferies, John Lynn
Assuntos: Adult ; Ataxia ; Biology and Life Sciences ; Cardiac arrhythmia ; Cardiology ; Cardiomyocytes ; Cardiomyopathy ; Case-Control Studies ; Cerebellar ataxia ; Cerebellum ; Complications and side effects ; Computed tomography ; Data analysis ; Development and progression ; Diabetes ; Disease ; Dorsal root ganglia ; Editing ; Female ; Fibrosis ; Friedreich Ataxia - complications ; Friedreich's ataxia ; Ganglia ; Genetic aspects ; Genotype & phenotype ; Heart ; Heart enlargement ; Heart failure ; Hospitals ; Humans ; Hypertrophy, Left Ventricular - diagnostic imaging ; Hypertrophy, Left Ventricular - pathology ; Internal medicine ; Intracellular ; Magnetic resonance imaging ; Magnetic Resonance Imaging, Cine - methods ; Male ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Methodology ; Myocardium - pathology ; Neurodegeneration ; Neurology ; Patients ; Positron emission ; Positron emission tomography ; Radiology ; Research and Analysis Methods ; Risk factors ; Spinal cord ; Tomography ; Ventricle ; Ventricular Remodeling ; Visualization ; Water content ; Young Adult
É parte de: PloS one, 2021-03, Vol.16 (3), p.e0246633-e0246633
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Competing Interests: The authors have read the journal’s policy and have the following competing interests: TGN has consultancy agreements with Parexel, Intrinsic Imaging, BMS, and Aprea Therapeutics unrelated to this research. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.
Descrição: Heart Failure (HF) is the most common cause of death in Friedreich's ataxia (FRDA), an inherited mitochondrial disease. Myocardial fibrosis and myocardial hypertrophy are well-documented autopsy features among FRDA patients with HF. To leverage the unique tissue characterization features of cardiac magnetic resonance (CMR) for characterizing myocardial remodeling in patients with genetically confirmed FRDA without HF and preserved left ventricular ejection fraction (LVEF > 55%). Twenty-seven FRDA's patients (age 27.6 ± 9.7 years, 15 women) and 10 healthy controls (32.6±7.3 years, 5 women) underwent a CMR for assessment of LV function, myocardial T1, late gadolinium enhancement (LGE), extracellular volume fraction (ECV), and intracellular water-lifetime (τic), a marker of cardiomyocyte size. As compared to controls, FRDA patients had a preserved LVEF (LVEF: 70.5±7.4% vs. 63.9±9.0%, P<0.058), larger LV mass index (LVMASSi: 61±21.7 vs. 45±4.2g/m2, P<0.02), and decreased LV end-diastolic volume index (LVEDVi 53.1±12.0 vs. 75.7±16.1ml/m2, P<0.001), compared with controls. Additionally, ECV and cardiomyocyte size (τic,) were larger in FRDA patients (ECV: 0.36 ±0.05 vs. 0.25±0.02, P<0.001; τic: 0.15±0.08 vs. 0.06±0.03 s, P = 0.02). ECV and τic were positively associated with LV mass-to-volume ratio (ECV: r = 0.57, P = 0.003; τic: r = 0.39; P = 0.05). LVMASSi and cardiomyocyte mass-index [(1-ECV)·LVMASSi] declined with age at the CMR exam, independent of the age at initial diagnosis. LV hypertrophy and concentric LV remodeling in FRDA are associated at the tissue level with an expansion of the ECV and an increase in cardiomyocyte size. The adverse tissue remodeling assessed by ECV and τic is associated with more severe cardiomyopathy classification, suggesting a role for these markers in tracking disease progression.
Editor: United States: Public Library of Science
Idioma: Inglês

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Pre-clinical left ventricular myocardial remodeling in patients with Friedreich's ataxia: A cardiac MRI study

Takazaki, Karen A G ; Quinaglia, Thiago ; Venancio, Thiago D ; Martinez, Alberto R M ; Shah, Ravi V ; Neilan, Tomas G ; Jerosch-Herold, Michael ; Coelho-Filho, Otávio R ; França, Jr, Marcondes C Jefferies, John Lynn

United States: Public Library of Science

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