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Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

Dhomen, Nathalie ; Reis-Filho, Jorge S. ; da Rocha Dias, Silvy ; Hayward, Robert ; Savage, Kay ; Delmas, Veronique ; Larue, Lionel ; Pritchard, Catrin ; Marais, Richard

Cancer cell, 2009-04, Vol.15 (4), p.294-303 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice
Autor: Dhomen, Nathalie ; Reis-Filho, Jorge S. ; da Rocha Dias, Silvy ; Hayward, Robert ; Savage, Kay ; Delmas, Veronique ; Larue, Lionel ; Pritchard, Catrin ; Marais, Richard
Assuntos: Animals ; Cell Differentiation ; CELLCYCLE ; Cellular Senescence ; Disease Models, Animal ; Humans ; Immunoenzyme Techniques ; Melanocytes - cytology ; Melanocytes - metabolism ; Melanoma - metabolism ; Melanoma - pathology ; Mice ; Mice, Nude ; Mice, Transgenic ; Nevus - genetics ; Nevus - metabolism ; Nevus - pathology ; Proto-Oncogene Proteins B-raf - physiology
É parte de: Cancer cell, 2009-04, Vol.15 (4), p.294-303
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: We show here that inducible expression of Braf V600E off the endogenous Braf gene in mouse melanocytes stimulates skin hyperpigmentation and the appearance of nevi harboring senescent melanocytes. Additionally, approximately 70% of Braf V600E mice develop melanomas that reproduce many of the cardinal histological and molecular features of human melanoma and whose cells can colonize the lungs of nude mice. We show that the tumor suppressor p16 INK4a is not required to induce melanocyte senescence and that its loss is not required for tumor progression, although it does regulate tumor penetrance and latency. Thus, we have developed a mouse model of melanoma driven by Braf V600E expressed at physiological levels that reflects the genetics and pathology of the human disease.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

Dhomen, Nathalie ; Reis-Filho, Jorge S. ; da Rocha Dias, Silvy ; Hayward, Robert ; Savage, Kay ; Delmas, Veronique ; Larue, Lionel ; Pritchard, Catrin ; Marais, Richard

United States: Elsevier Inc

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