Idioma:

Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility

Butts, Samantha F ; Seifer, David B ; Koelper, Nathanael ; Senapati, Suneeta ; Sammel, Mary D ; Hoofnagle, Andrew N ; Kelly, Andrea ; Krawetz, Steven A ; Santoro, Nanette ; Zhang, Heping ; Diamond, Michael P ; Legro, Richard S

The journal of clinical endocrinology and metabolism, 2019-02, Vol.104 (2), p.369-378 [Periódico revisado por pares]

Washington, DC: Endocrine Society

Texto completo disponível

Citações Citado por

Enviar para

Título:
Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility
Autor: Butts, Samantha F ; Seifer, David B ; Koelper, Nathanael ; Senapati, Suneeta ; Sammel, Mary D ; Hoofnagle, Andrew N ; Kelly, Andrea ; Krawetz, Steven A ; Santoro, Nanette ; Zhang, Heping ; Diamond, Michael P ; Legro, Richard S
Assuntos: 25-Hydroxyvitamin D ; Abortion ; Adult ; Clinical s ; Diagnosis ; Female ; Female infertility ; Humans ; Infertility ; Infertility, Female - blood ; Infertility, Female - etiology ; Infertility, Female - therapy ; Nutrient deficiency ; Ovulation ; Ovulation Induction - statistics & numerical data ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - complications ; Pregnancy ; Pregnancy Outcome ; Randomized Controlled Trials as Topic ; Retrospective Studies ; Vitamin D ; Vitamin D - blood ; Vitamin D deficiency ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - etiology ; Vitamin deficiency ; Vitamins ; Young Adult
É parte de: The journal of clinical endocrinology and metabolism, 2019-02, Vol.104 (2), p.369-378
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
S.F.B. and D.B.S. are co-first authors.
M.P.D. and R.S.L. are co-senior authors.
Descrição: Abstract Context The impact of vitamin D deficiency on the success of ovarian stimulation according to underlying infertility diagnosis has not been investigated. Objective To evaluate the relationship between vitamin D deficiency and reproductive outcomes after ovarian stimulation in women with either polycystic ovary syndrome (PCOS) or unexplained infertility. Design Retrospective cohort study. Setting Analysis of randomized controlled trial (RCT) data. Participants Participants from the Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) RCT (n = 607); participants from the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) RCT of unexplained infertility (n = 647). Interventions Serum 25(OH)D levels measured in banked sera. Main Outcome Measures Primary: live birth; secondary: ovulation (PPCOS II), pregnancy, and early pregnancy loss. Results In PPCOS II, subjects with vitamin D deficiency [25(OH)D < 20 ng/mL or 50 nmol/L] were less likely to ovulate (adjusted OR, 0.82; 95% CI, 0.68 to 0.99; P = 0.04) and experienced a 40% lower chance of live birth (adjusted OR, 0.63; 95% CI, 0.41 to 0.98; P = 0.04) than those not deficient. In AMIGOS, no significant association between vitamin D deficiency and live birth was noted. In pregnant subjects from both studies, vitamin D deficiency was associated with elevated risk of early pregnancy loss (OR, 1.6; 95% CI, 1.0 to 2.6; P = 0.05). Conclusions In this investigation of women pursuing ovarian stimulation, the association between vitamin D deficiency and diminished live birth relied on carrying the diagnosis of PCOS and was not observed in unexplained infertility. Given the generally modest success of ovarian stimulation, addressing vitamin D deficiency may prove an important treatment adjunct for many infertile women. In women with infertility undergoing ovarian stimulation, pretreatment vitamin D deficiency is associated with diminished live birth rates in those with PCOS but not those with unexplained infertility.
Editor: Washington, DC: Endocrine Society
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility

Butts, Samantha F ; Seifer, David B ; Koelper, Nathanael ; Senapati, Suneeta ; Sammel, Mary D ; Hoofnagle, Andrew N ; Kelly, Andrea ; Krawetz, Steven A ; Santoro, Nanette ; Zhang, Heping ; Diamond, Michael P ; Legro, Richard S

Washington, DC: Endocrine Society

Buscando em bases de dados remotas. Favor aguardar.