Idioma:

CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation

Narendra, Varun ; Rocha, Pedro P. ; An, Disi ; Raviram, Ramya ; Skok, Jane A. ; Mazzoni, Esteban O. ; Reinberg, Danny

Science (American Association for the Advancement of Science), 2015-02, Vol.347 (6225), p.1017-1021 [Periódico revisado por pares]

United States: American Association for the Advancement of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation
Autor: Narendra, Varun ; Rocha, Pedro P. ; An, Disi ; Raviram, Ramya ; Skok, Jane A. ; Mazzoni, Esteban O. ; Reinberg, Danny
Assuntos: Ablation ; Activation ; Animals ; Binding sites ; CCCTC-Binding Factor ; Cell Differentiation - genetics ; Chromatin - chemistry ; Chromatin - genetics ; Chromatin - metabolism ; Clusters ; Differentiation ; Dogs ; Embryonic Stem Cells - cytology ; Gene expression ; Gene Expression Regulation ; Genes ; Genes, Homeobox ; Humans ; Mice ; Motor Neurons - cytology ; Multigene Family ; Neck ; Protein Structure, Tertiary ; Proteins ; Rats ; Repressor Proteins - chemistry ; Repressor Proteins - genetics ; Repressor Proteins - metabolism
É parte de: Science (American Association for the Advancement of Science), 2015-02, Vol.347 (6225), p.1017-1021
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Polycomb and Trithorax group proteins encode the epigenetic memory of cellular positional identity by establishing inheritable domains of repressive and active chromatin within the Hox clusters. Here we demonstrate that the CCCTC-binding factor (CTCF) functions to insulate these adjacent yet antagonistic chromatin domains during embryonic stem cell differentiation into cervical motor neurons. Deletion of CTCF binding sites within the Hox clusters results in the expansion of active chromatin into the repressive domain. CTCF functions as an insulator by organizing Hox clusters into spatially disjoint domains. Ablation of CTCF binding disrupts topological boundaries such that caudal Hox genes leave the repressed domain and become subject to transcriptional activation. Hence, CTCF is required to insulate facultative heterochromatin from impinging euchromatin to produce discrete positional identities.
Editor: United States: American Association for the Advancement of Science
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation

Narendra, Varun ; Rocha, Pedro P. ; An, Disi ; Raviram, Ramya ; Skok, Jane A. ; Mazzoni, Esteban O. ; Reinberg, Danny

United States: American Association for the Advancement of Science

Buscando em bases de dados remotas. Favor aguardar.