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Toxicity of a polymer-graphene oxide composite against bacterial planktonic cells, biofilms, and mammalian cells

Mejías Carpio, Isis E ; Santos, Catherine M ; Wei, Xin ; Rodrigues, Debora F

Nanoscale, 2012-08, Vol.4 (15), p.4746 [Periódico revisado por pares]

England

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Título:
Toxicity of a polymer-graphene oxide composite against bacterial planktonic cells, biofilms, and mammalian cells
Autor: Mejías Carpio, Isis E ; Santos, Catherine M ; Wei, Xin ; Rodrigues, Debora F
Assuntos: Animals ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - toxicity ; Bacillus subtilis - drug effects ; Bacillus subtilis - physiology ; Biofilms - drug effects ; Carbazoles - chemistry ; Cupriavidus - drug effects ; Cupriavidus - physiology ; Escherichia coli - drug effects ; Escherichia coli - physiology ; Graphite - chemistry ; Mice ; Nanocomposites - chemistry ; Nanocomposites - toxicity ; NIH 3T3 Cells ; Oxides - chemistry ; Polymers - chemistry ; Rhodococcus - drug effects ; Rhodococcus - physiology
É parte de: Nanoscale, 2012-08, Vol.4 (15), p.4746
Descrição: It is critical to develop highly effective antimicrobial agents that are not harmful to humans and do not present adverse effects on the environment. Although antimicrobial studies of graphene-based nanomaterials are still quite limited, some researchers have paid particular attention to such nanocomposites as promising candidates for the next generation of antimicrobial agents. The polyvinyl-N-carbazole (PVK)-graphene oxide (GO) nanocomposite (PVK-GO), which contains only 3 wt% of GO well-dispersed in a 97 wt% PVK matrix, presents excellent antibacterial properties without significant cytotoxicity to mammalian cells. The high polymer content in this nanocomposite makes future large-scale material manufacturing possible in a high-yield process of adiabatic bulk polymerization. In this study, the toxicity of PVK-GO was assessed with planktonic microbial cells, biofilms, and NIH 3T3 fibroblast cells. The antibacterial effects were evaluated against two Gram-negative bacteria: Escherichia coli and Cupriavidus metallidurans; and two Gram-positive bacteria: Bacillus subtilis and Rhodococcus opacus. The results show that the PVK-GO nanocomposite presents higher antimicrobial effects than the pristine GO. The effectiveness of the PVK-GO in solution was demonstrated as the nanocomposite "encapsulated" the bacterial cells, which led to reduced microbial metabolic activity and cell death. The fact that the PVK-GO did not present significant cytotoxicity to fibroblast cells offers a great opportunity for potential applications in important biomedical and industrial fields.
Editor: England
Idioma: Inglês

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Toxicity of a polymer-graphene oxide composite against bacterial planktonic cells, biofilms, and mammalian cells

Mejías Carpio, Isis E ; Santos, Catherine M ; Wei, Xin ; Rodrigues, Debora F

England

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