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Increased serum levels of interleukin-8 in patients with tension-type headache

Domingues, Renan B ; Duarte, Halina ; Rocha, Natália P ; Teixeira, Antonio L

Cephalalgia, 2015-08, Vol.35 (9), p.801-806 [Periódico revisado por pares]

London, England: SAGE Publications

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  • Título:
    Increased serum levels of interleukin-8 in patients with tension-type headache
  • Autor: Domingues, Renan B ; Duarte, Halina ; Rocha, Natália P ; Teixeira, Antonio L
  • Assuntos: Adult ; Aged ; Chemokines - blood ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Interleukin-8 - blood ; Male ; Middle Aged ; Tension-Type Headache - blood ; Tension-Type Headache - physiopathology ; Young Adult
  • É parte de: Cephalalgia, 2015-08, Vol.35 (9), p.801-806
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: Background and objectives The pathophysiology of tension-type headache is not well understood. Increased peripheral levels of pro-inflammatory cytokines may act as mediators of several chronic pain disorders. The aim of the present study was to investigate the peripheral levels of chemokines in patients with tension-type headache. Methods This was a cross sectional study evaluating serum levels of chemokines in age and sex-matched tension-type headache patients, ictally and interictally, and control participants. Beck Depression and Anxiety Inventories were recorded. Serum levels of monocyte chemoattractant protein-1, macrophage inflammatory protein 1α, regulated on activation, normal T cell expressed and secreted, eotaxin, eotaxin-2, interleukin-8, interferon gamma induced protein-10 were measured by enzyme-linked immunosorbent assay. Results A total of 96 participants (48 tension-type headache, 48 controls) were included. Interleukin-8 levels were significantly increased in patients with tension-type headache when compared to controls (413.8 (123.4–1756.3) and 329 (107.8–955.6), respectively, P = 0.025). Anxiety and depression scores were higher in patients with tension-type headache but interleukin-8 increase in tension-type headache patients persisted after controlling for anxiety and depression symptoms. Patients with headache at the time of assessment had increased monocyte chemoattractant protein-1 levels when compared with patients without headache (2809.3 (1101–6122.2) and 1630.2 (669.3–31056.8), respectively P = 0.026). Patients with episodic and chronic tension-type headache had no significant differences in serum chemokines levels. Conclusion Interleukin-8 was increased in tension-type headache and monocyte chemoattractant protein-1 was higher in tension-type headache patients with headache, suggesting that pro-inflammatory mechanisms may participate in tension-type headache pathophysiology.
  • Editor: London, England: SAGE Publications
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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