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The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease

Barone, Paolo ; Antonini, Angelo ; Colosimo, Carlo ; Marconi, Roberto ; Morgante, Letterio ; Avarello, Tania P. ; Bottacchi, Eugenio ; Cannas, Antonino ; Ceravolo, Gabriella ; Ceravolo, Roberto ; Cicarelli, Giulio ; Gaglio, Roberto M. ; Giglia, Rosa M. ; Iemolo, Francesco ; Manfredi, Michela ; Meco, Giuseppe ; Nicoletti, Alessandra ; Pederzoli, Massimo ; Petrone, Alfredo ; Pisani, Antonio ; Pontieri, Francesco E. ; Quatrale, Rocco ; Ramat, Silvia ; Scala, Rosanna ; Volpe, Giuseppe ; Zappulla, Salvatore ; Bentivoglio, Anna Rita ; Stocchi, Fabrizio ; Trianni, Giorgio ; Dotto, Paolo Del

Movement disorders, 2009-08, Vol.24 (11), p.1641-1649 [Periódico revisado por pares]

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The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
Autor: Barone, Paolo ; Antonini, Angelo ; Colosimo, Carlo ; Marconi, Roberto ; Morgante, Letterio ; Avarello, Tania P. ; Bottacchi, Eugenio ; Cannas, Antonino ; Ceravolo, Gabriella ; Ceravolo, Roberto ; Cicarelli, Giulio ; Gaglio, Roberto M. ; Giglia, Rosa M. ; Iemolo, Francesco ; Manfredi, Michela ; Meco, Giuseppe ; Nicoletti, Alessandra ; Pederzoli, Massimo ; Petrone, Alfredo ; Pisani, Antonio ; Pontieri, Francesco E. ; Quatrale, Rocco ; Ramat, Silvia ; Scala, Rosanna ; Volpe, Giuseppe ; Zappulla, Salvatore ; Bentivoglio, Anna Rita ; Stocchi, Fabrizio ; Trianni, Giorgio ; Dotto, Paolo Del
Assuntos: Aged ; Antiparkinson Agents - therapeutic use ; Anxiety - epidemiology ; Anxiety - etiology ; Anxiety - psychology ; Biological and medical sciences ; cognition ; Cognition Disorders - epidemiology ; Cognition Disorders - etiology ; Cognition Disorders - psychology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Depression - epidemiology ; Depression - etiology ; Depression - psychology ; Fatigue - epidemiology ; Fatigue - etiology ; Fatigue - psychology ; Female ; Gastrointestinal Diseases - epidemiology ; Gastrointestinal Diseases - etiology ; Gastrointestinal Diseases - psychology ; Humans ; Italy - epidemiology ; Male ; Medical sciences ; Middle Aged ; Neurology ; nonmotor symptoms ; Olfaction Disorders - epidemiology ; Olfaction Disorders - etiology ; Olfaction Disorders - psychology ; Pain - epidemiology ; Pain - etiology ; Pain - psychology ; Parkinson Disease - complications ; Parkinson Disease - drug therapy ; Parkinson Disease - psychology ; Parkinson's disease ; psychiatric symptoms ; Quality of Life ; Sleep Disorders, Intrinsic - epidemiology ; Sleep Disorders, Intrinsic - etiology ; Sleep Disorders, Intrinsic - psychology ; Urination Disorders - epidemiology ; Urination Disorders - etiology ; Urination Disorders - psychology
É parte de: Movement disorders, 2009-08, Vol.24 (11), p.1641-1649
Notas: Members of the "PRIAMO Study Group" are listed as an Appendix. Potential conflict of interest: Angelo Antonini, Paolo Barone, Carlo Colosimo, Roberto Marconi, and Letterio Morgante have received consultancy fees from Boehringer-Ingelheim, Italy.
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ArticleID:MDS22643
Members of the “PRIAMO Study Group” are listed as an
Potential conflict of interest: Angelo Antonini, Paolo Barone, Carlo Colosimo, Roberto Marconi, and Letterio Morgante have received consultancy fees from Boehringer‐Ingelheim, Italy.
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Descrição: We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0–32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ‐39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. © 2009 Movement Disorder Society
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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