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Long-Term Nightshift Work and Breast Cancer Risk: An Updated Systematic Review and Meta-Analysis with Special Attention to Menopausal Status and to Recent Nightshift Work

Schwarz, Christine ; Pedraza-Flechas, Ana María ; Pastor-Barriuso, Roberto ; Lope, Virginia ; de Larrea, Nerea Fernández ; Jiménez-Moleón, José Juan ; Pollán, Marina ; Pérez-Gómez, Beatriz

Cancers, 2021-11, Vol.13 (23), p.5952 [Periódico revisado por pares]

Basel: MDPI AG

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  • Título:
    Long-Term Nightshift Work and Breast Cancer Risk: An Updated Systematic Review and Meta-Analysis with Special Attention to Menopausal Status and to Recent Nightshift Work
  • Autor: Schwarz, Christine ; Pedraza-Flechas, Ana María ; Pastor-Barriuso, Roberto ; Lope, Virginia ; de Larrea, Nerea Fernández ; Jiménez-Moleón, José Juan ; Pollán, Marina ; Pérez-Gómez, Beatriz
  • Assuntos: Age ; Breast cancer ; Circadian rhythm ; Circadian rhythms ; Female employees ; Hormone replacement therapy ; menopausal status ; Menopause ; Meta-analysis ; nightshift work ; occupational exposure ; Pacemakers ; Post-menopause ; recent exposure ; Reviews ; Systematic Review ; Tumors ; Womens health
  • É parte de: Cancers, 2021-11, Vol.13 (23), p.5952
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: This systematic review discusses long-term NSW and female BC risk, with special attention to differences between pre- and postmenopausal BC, to test the association with recent NSW. The review follows PRISMA guidelines (Prospero registry: CRD42018102515). We searched PubMed, Embase, and WOS for case–control, nested case–control, and cohort studies addressing long-term NSW (≥15 years) as risk exposure and female BC as outcome until 31 December 2020. Risk of bias was evaluated with the Newcastle–Ottawa scale. Eighteen studies were finally included (eight cohorts; five nested case–control; five case–control). We performed meta-analyses on long-term NSW and BC risk; overall and by menopausal status; a subanalysis on recent long-term NSW, based on studies involving predominantly women below retirement age; and a dose–response meta-analysis on NSW duration. The pooled estimate for long-term NSW and BC was 1.13 (95%CI = 1.01–1.27; 18 studies, I2 = 56.8%, p = 0.002). BC risk increased 4.7% per 10 years of NSW (95%CI = 0.94–1.09; 16 studies, I2 = 33.4%, p = 0.008). The pooled estimate for premenopausal BC was 1.27 (95%CI = 0.96–1.68; six studies, I2 = 32.0%, p = 0.196) and for postmenopausal BC 1.05 (95%CI = 0.90–1.24,I2 = 52.4%; seven studies, p = 0.050). For recent long-term exposure, the pooled estimate was 1.23 (95%CI = 1.06–1.42; 15 studies; I2 = 48.4%, p = 0.018). Our results indicate that long-term NSW increases the risk for BC and that menopausal status and time since exposure might be relevant.
  • Editor: Basel: MDPI AG
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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