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Clinical and immunological aspects and outcome of a Brazilian cohort of 414 patients with systemic lupus erythematosus (SLE): comparison between childhood-onset, adult-onset, and late-onset SLE

das Chagas Medeiros, M M ; Bezerra, M Campos ; Braga, F N Holanda Ferreira ; da Justa Feijão, M R Melo ; Gois, A C Rodrigues ; Rebouças, V C do Rosário ; de Carvalho, T M Amorim Zaranza ; Carvalho, L N Solon ; Ribeiro, ÁT Mendes

Lupus, 2016-04, Vol.25 (4), p.355-363 [Periódico revisado por pares]

London, England: SAGE Publications

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Título:
Clinical and immunological aspects and outcome of a Brazilian cohort of 414 patients with systemic lupus erythematosus (SLE): comparison between childhood-onset, adult-onset, and late-onset SLE
Autor: das Chagas Medeiros, M M ; Bezerra, M Campos ; Braga, F N Holanda Ferreira ; da Justa Feijão, M R Melo ; Gois, A C Rodrigues ; Rebouças, V C do Rosário ; de Carvalho, T M Amorim Zaranza ; Carvalho, L N Solon ; Ribeiro, ÁT Mendes
Assuntos: Adolescent ; Adult ; Age of Onset ; Anti-DNA antibodies ; Antibodies ; Antibodies, Antinuclear - blood ; Antibodies, Antiphospholipid - blood ; Antiphospholipid antibodies ; Biomarkers - blood ; Brazil - epidemiology ; Cardiovascular diseases ; Child ; Child, Preschool ; Children ; Comorbidity ; Disease Progression ; Environmental factors ; Female ; Glucocorticoids - therapeutic use ; Hospitals, University ; Humans ; Immunological aspects ; Immunology ; Immunosuppressive agents ; Immunosuppressive Agents - therapeutic use ; Lupus ; Lupus Erythematosus, Systemic - diagnosis ; Lupus Erythematosus, Systemic - drug therapy ; Lupus Erythematosus, Systemic - immunology ; Lupus Erythematosus, Systemic - mortality ; Lupus Nephritis - diagnosis ; Lupus Nephritis - drug therapy ; Lupus Nephritis - immunology ; Lupus Nephritis - mortality ; Lymphopenia ; Male ; Middle Aged ; Mortality ; Nephritis ; Prednisone ; Prevalence ; Remission ; Remission Induction ; Retrospective Studies ; Risk Factors ; Systemic lupus erythematosus ; Time Factors ; Treatment Outcome ; Young Adult
É parte de: Lupus, 2016-04, Vol.25 (4), p.355-363
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The clinical expression of systemic lupus erythematosus (SLE) is influenced by genetic and environmental factors and therefore varies between ethnicities. Information on the epidemiology of SLE in Brazil is scarce and practically limited to studies conducted in socioeconomically developed regions (South and Southeast). The objective of this study was to describe the clinical and immunological aspects and outcome of a cohort of patients with SLE treated at a university hospital in northeastern Brazil and compare patterns related to age at onset: childhood (cSLE), adult (aSLE), and late (lSLE). A random sample of 414 records (women: 93.5%) were reviewed. The mean age at SLE onset and the mean disease duration were 28.9 ± 10.9 years and 10.2 ± 6.6 years, respectively. Most patients had aSLE (n = 338; 81.6%), followed by cSLE (n = 60; 14.5%) and lSLE (n = 16; 3.9%). The female/male ratio was 6.5:1 in cSLE and 16.8:1 in aSLE; in lSLE, all patients were female (p = 0.05). During follow-up, the cSLE group presented higher rates of nephritis (70% vs. 52.9% vs. 12.5%; p = 0.0001) and leuko/lymphopenia (61.7% vs. 43.8% vs. 56.2%; p = 0.02). No significant differences were found for anti-dsDNA, anti-Sm, and antiphospholipid antibodies. Treatment with immunosuppressants was significantly more common, and higher doses of prednisone were used, in cSLE. The prevalence of cardiovascular diseases were more frequent in lSLE (p = 0.03). No significant differences were found between the three groups with regard to mean damage accrual (SDI), remission, and mortality. Although cSLE presented higher rates of nephritis and leuko/lymphopenia, more frequent use of immunosuppressants and higher prednisone doses than aSLE and lSLE, the three groups did not differ significantly with regard to damage accrual, remission, and mortality.
Editor: London, England: SAGE Publications
Idioma: Inglês

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Clinical and immunological aspects and outcome of a Brazilian cohort of 414 patients with systemic lupus erythematosus (SLE): comparison between childhood-onset, adult-onset, and late-onset SLE

das Chagas Medeiros, M M ; Bezerra, M Campos ; Braga, F N Holanda Ferreira ; da Justa Feijão, M R Melo ; Gois, A C Rodrigues ; Rebouças, V C do Rosário ; de Carvalho, T M Amorim Zaranza ; Carvalho, L N Solon ; Ribeiro, ÁT Mendes

London, England: SAGE Publications

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