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Cord blood 25(OH)-vitamin D deficiency and childhood asthma, allergy and eczema: the COPSAC2000 birth cohort study

Chawes, Bo L ; Bønnelykke, Klaus ; Jensen, Pia F ; Schoos, Ann-Marie M ; Heickendorff, Lene ; Bisgaard, Hans Lee, Yungling Leo

PloS one, 2014-06, Vol.9 (6), p.e99856-e99856 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Cord blood 25(OH)-vitamin D deficiency and childhood asthma, allergy and eczema: the COPSAC2000 birth cohort study
Autor: Chawes, Bo L ; Bønnelykke, Klaus ; Jensen, Pia F ; Schoos, Ann-Marie M ; Heickendorff, Lene ; Bisgaard, Hans
Lee, Yungling Leo
Assuntos: 25-Hydroxyvitamin D ; Adult ; Age ; Age of Onset ; Algorithms ; Allergic rhinitis ; Allergies ; Asthma ; Asthma - blood ; Asthma - epidemiology ; Biochemistry ; Biomarkers ; Blood ; Child ; Child, Preschool ; Childbirth & labor ; Children ; Clinical trials ; Cohort analysis ; Cohort Studies ; Cord blood ; Denmark - epidemiology ; Diet ; Dietary intake ; Dietary supplements ; Eczema ; Eczema - blood ; Eczema - epidemiology ; Epidemiology ; Female ; Fetal Blood - chemistry ; Food allergies ; Health sciences ; Humans ; Hypersensitivity ; Hypersensitivity - blood ; Hypersensitivity - epidemiology ; Hypotheses ; Infant ; Infant, Newborn ; Infections ; Lungs ; Male ; Medicine and Health Sciences ; Nutrient deficiency ; Offspring ; Pediatrics ; Pregnancy ; Pregnancy Complications - blood ; Pregnancy Complications - epidemiology ; Respiratory function ; Rhinitis ; Risk ; Skin diseases ; Studies ; Supplementation ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - analysis ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - epidemiology ; Vitamin deficiency ; Young Adult
É parte de: PloS one, 2014-06, Vol.9 (6), p.e99856-e99856
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Conceived and designed the experiments: BLC KB HB. Performed the experiments: BLC KB PFJ AMS. Analyzed the data: BLC KB PFJ AMS HB. Contributed reagents/materials/analysis tools: LH. Wrote the paper: BLC KB PFJ AMS LH HB. The guarantor of the study who has been responsible for the integrity of the work as a whole, from conception and design to conduct of the study and acquisition of data, analysis and interpretation of data and writing of the manuscript: HB. Responsible for data analysis, interpretation and writing the manuscript: BLC KB PFJ AMS LH. Wrote the first draft of the manuscript: BC. No honorarium, grant, or other form of payment was given to anyone to produce the manuscript. All co-authors have contributed substantially to the analyses and interpretation of the data, and have provided important intellectual input and approval of the final version of the manuscript.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Epidemiological studies have suggested an association between maternal vitamin D dietary intake during pregnancy and risk of asthma and allergy in the offspring. However, prospective clinical studies on vitamin D measured in cord blood and development of clinical end-points are sparse. To investigate the interdependence of cord blood 25-hydroxyvitamin D (25(OH)-Vitamin D) level and investigator-diagnosed asthma- and allergy-related conditions during preschool-age. Cord blood 25(OH)-Vitamin D level was measured in 257 children from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2000) at-risk mother-child cohort. Troublesome lung symptoms (TROLS), asthma, respiratory infections, allergic rhinitis, and eczema, at age 0-7 yrs were diagnosed exclusively by the COPSAC pediatricians strictly adhering to predefined algorithms. Objective assessments of lung function and sensitization were performed repeatedly from birth. After adjusting for season of birth, deficient cord blood 25(OH)-Vitamin D level (<50 nmol/L) was associated with a 2.7-fold increased risk of recurrent TROLS (HR = 2.65; 95% CI = 1.02-6.86), but showed no association with respiratory infections or asthma. We saw no association between cord blood 25(OH)-Vitamin D level and lung function, sensitization, rhinitis or eczema. The effects were unaffected from adjusting for multiple lifestyle factors. Cord blood 25(OH)-Vitamin D deficiency associated with increased risk of recurrent TROLS till age 7 years. Randomized controlled trials of vitamin D supplementation during pregnancy are needed to prove causality.
Editor: United States: Public Library of Science
Idioma: Inglês

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Cord blood 25(OH)-vitamin D deficiency and childhood asthma, allergy and eczema: the COPSAC2000 birth cohort study

Chawes, Bo L ; Bønnelykke, Klaus ; Jensen, Pia F ; Schoos, Ann-Marie M ; Heickendorff, Lene ; Bisgaard, Hans Lee, Yungling Leo

United States: Public Library of Science

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