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Genetic control of variability in subcortical and intracranial volumes

Córdova-Palomera, Aldo ; van der Meer, Dennis ; Kaufmann, Tobias ; Bettella, Francesco ; Wang, Yunpeng ; Alnæs, Dag ; Doan, Nhat Trung ; Agartz, Ingrid ; Bertolino, Alessandro ; Buitelaar, Jan K ; Coynel, David ; Djurovic, Srdjan ; Dørum, Erlend S ; Espeseth, Thomas ; Fazio, Leonardo ; Franke, Barbara ; Frei, Oleksandr ; Håberg, Asta ; Le Hellard, Stephanie ; Jönsson, Erik G ; Kolskår, Knut K ; Lund, Martina J ; Moberget, Torgeir ; Nordvik, Jan E ; Nyberg, Lars ; Papassotiropoulos, Andreas ; Pergola, Giulio ; de Quervain, Dominique ; Rampino, Antonio ; Richard, Genevieve ; Rokicki, Jaroslav ; Sanders, Anne-Marthe ; Schwarz, Emanuel ; Smeland, Olav B ; Steen, Vidar M ; Starrfelt, Jostein ; Sønderby, Ida E ; Ulrichsen, Kristine M ; Andreassen, Ole A ; Westlye, Lars T

Molecular psychiatry, 2021-08, Vol.26 (8), p.3876-3883 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Genetic control of variability in subcortical and intracranial volumes
Autor: Córdova-Palomera, Aldo ; van der Meer, Dennis ; Kaufmann, Tobias ; Bettella, Francesco ; Wang, Yunpeng ; Alnæs, Dag ; Doan, Nhat Trung ; Agartz, Ingrid ; Bertolino, Alessandro ; Buitelaar, Jan K ; Coynel, David ; Djurovic, Srdjan ; Dørum, Erlend S ; Espeseth, Thomas ; Fazio, Leonardo ; Franke, Barbara ; Frei, Oleksandr ; Håberg, Asta ; Le Hellard, Stephanie ; Jönsson, Erik G ; Kolskår, Knut K ; Lund, Martina J ; Moberget, Torgeir ; Nordvik, Jan E ; Nyberg, Lars ; Papassotiropoulos, Andreas ; Pergola, Giulio ; de Quervain, Dominique ; Rampino, Antonio ; Richard, Genevieve ; Rokicki, Jaroslav ; Sanders, Anne-Marthe ; Schwarz, Emanuel ; Smeland, Olav B ; Steen, Vidar M ; Starrfelt, Jostein ; Sønderby, Ida E ; Ulrichsen, Kristine M ; Andreassen, Ole A ; Westlye, Lars T
Assuntos: Amygdala ; Anatomy ; Association analysis ; Brain - diagnostic imaging ; Brain architecture ; Cerebral cortex ; Environmental conditions ; Genetic aspects ; Genetic control ; Genetic regulation ; Genetic variability ; Genome-Wide Association Study ; Genomes ; Globus pallidus ; Health aspects ; Heritability ; Humans ; Life span ; Magnetic Resonance Imaging ; Medicin och hälsovetenskap ; Mental health ; Middle Aged ; Nucleus accumbens ; Phenotypic plasticity ; Phenotypic variations ; Physiological aspects ; Psychiatric research ; Putamen ; Thalamus
É parte de: Molecular psychiatry, 2021-08, Vol.26 (8), p.3876-3883
Notas: NFR/223273
Descrição: Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology to perform genome-wide association analysis of mean and variance in ten key brain features (accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, intracranial volume, cortical surface area, and cortical thickness), integrating genetic and neuroanatomical data from a large lifespan sample (n = 25,575 individuals; 8-89 years, mean age 51.9 years). We identify genetic loci associated with phenotypic variability in thalamus volume and cortical thickness. The variance-controlling loci involved genes with a documented role in brain and mental health and were not associated with the mean anatomical volumes. This proof-of-principle of the hypothesis of a genetic regulation of brain volume variability contributes to establishing the genetic basis of phenotypic variance (i.e., heritability), allows identifying different degrees of brain robustness across individuals, and opens new research avenues in the search for mechanisms controlling brain and mental health.
Editor: England: Nature Publishing Group
Idioma: Inglês;Norueguês

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Genetic control of variability in subcortical and intracranial volumes

England: Nature Publishing Group

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