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N-linked oligosaccharide chains of Sendai virus fusion protein determine the interaction with endoplasmic reticulum molecular chaperones

Tamura, Taku ; Yamashita, Tetsuro ; Segawa, Hiroaki ; Taira, Hideharu

FEBS letters, 2002-02, Vol.513 (2-3), p.153-158 [Periódico revisado por pares]

England: Elsevier B.V

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Título:
N-linked oligosaccharide chains of Sendai virus fusion protein determine the interaction with endoplasmic reticulum molecular chaperones
Autor: Tamura, Taku ; Yamashita, Tetsuro ; Segawa, Hiroaki ; Taira, Hideharu
Assuntos: BiP ; Calcium-Binding Proteins - metabolism ; Calnexin ; CHAPS, 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane-sulfonate ; CNX, calnexin ; CRT, calreticulin ; CST, castanospermine ; Endoplasmic Reticulum - metabolism ; ER, endoplasmic reticulum ; ERp57 ; F protein, Sendai virus fusion protein ; Gene Expression - drug effects ; Glycosylation ; Heat-Shock Proteins - metabolism ; HeLa Cells ; Humans ; Indolizines - pharmacology ; Isomerases - metabolism ; Molecular Chaperones - metabolism ; Mutation ; N-linked oligosaccharide chain ; Oligosaccharides - metabolism ; PBS, phosphate-buffered saline ; Precipitin Tests ; Protein Disulfide-Isomerases ; Protein Folding ; Sendai virus fusion protein ; TBS, Tris-buffered saline ; Viral Fusion Proteins - chemistry ; Viral Fusion Proteins - genetics ; Viral Fusion Proteins - metabolism
É parte de: FEBS letters, 2002-02, Vol.513 (2-3), p.153-158
Notas: ObjectType-Article-2
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Descrição: The selectivity and individual roles of the N-linked oligosaccharide chains of Sendai virus fusion protein (F protein) in the interaction with endoplasmic reticulum molecular chaperones were investigated by analyses of transient expression of single N-glycosylation mutants and sequential immunoprecipitation. We demonstrated differential interactions depending on the location of the N-linked oligosaccharide chain, and showed that these interactions were correlated with the folding and transport of F proteins. Moreover, mutant F proteins that lacked the specific N-linked oligosaccharide chains required for disulfide bond formation showed increased association with ERp57.
Editor: England: Elsevier B.V
Idioma: Inglês

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N-linked oligosaccharide chains of Sendai virus fusion protein determine the interaction with endoplasmic reticulum molecular chaperones

Tamura, Taku ; Yamashita, Tetsuro ; Segawa, Hiroaki ; Taira, Hideharu

England: Elsevier B.V

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