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Dendritic Cell Vaccines: A Promising Approach in the Fight against Ovarian Cancer

Caro, Aarushi Audhut ; Deschoemaeker, Sofie ; Allonsius, Lize ; Coosemans, An ; Laoui, Damya

Cancers, 2022-08, Vol.14 (16), p.4037 [Periódico revisado por pares]

Basel: MDPI AG

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Título:
Dendritic Cell Vaccines: A Promising Approach in the Fight against Ovarian Cancer
Autor: Caro, Aarushi Audhut ; Deschoemaeker, Sofie ; Allonsius, Lize ; Coosemans, An ; Laoui, Damya
Assuntos: Antigens ; Cancer therapies ; Cancer vaccines ; Chemotherapy ; Clinical trials ; Dendrites ; dendritic cell vaccines ; Dendritic cells ; Health aspects ; Immunotherapy ; Lymphocytes ; Malignancy ; Melanoma ; Metastasis ; Mutation ; Ovarian cancer ; Patients ; Prevention ; Product development ; Response rates ; Review ; Skin cancer ; Success ; T cells ; Tumor microenvironment ; tumor-antigens ; Tumors ; Vaccination ; Vaccines
É parte de: Cancers, 2022-08, Vol.14 (16), p.4037
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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These authors contributed equally to this work.
Descrição: Ovarian cancer (OC) is the deadliest gynecological malignancy in developed countries and is the seventh-highest cause of death in women diagnosed with cancer worldwide. Currently, several therapies are in use against OC, including debulking surgery, chemotherapy, as well as targeted therapies. Even though the current standard-of-care therapies improve survival, a vast majority of OC patients relapse. Additionally, immunotherapies have only resulted in meager patient outcomes, potentially owing to the intricate immunosuppressive nexus within the tumor microenvironment. In this scenario, dendritic cell (DC) vaccination could serve as a potential addition to the therapeutic options available against OC. In this review, we provide an overview of current therapies in OC, focusing on immunotherapies. Next, we highlight the potential of using DC vaccines in OC by underscoring the different DC subsets and their functions in OC. Finally, we provide an overview of the advances and pitfalls of current DC vaccine strategies in OC while providing future perspectives that could improve patient outcomes.
Editor: Basel: MDPI AG
Idioma: Inglês

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Dendritic Cell Vaccines: A Promising Approach in the Fight against Ovarian Cancer

Caro, Aarushi Audhut ; Deschoemaeker, Sofie ; Allonsius, Lize ; Coosemans, An ; Laoui, Damya

Basel: MDPI AG

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