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Trial watch: dendritic cell vaccination for cancer immunotherapy

Sprooten, Jenny ; Ceusters, Jolien ; Coosemans, An ; Agostinis, Patrizia ; De Vleeschouwer, Steven ; Zitvogel, Laurence ; Kroemer, Guido ; Galluzzi, Lorenzo ; Garg, Abhishek D.

Oncoimmunology, 2019-11, Vol.8 (11), p.e1638212-e1638212 [Periódico revisado por pares]

United States: Taylor & Francis

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Título:
Trial watch: dendritic cell vaccination for cancer immunotherapy
Autor: Sprooten, Jenny ; Ceusters, Jolien ; Coosemans, An ; Agostinis, Patrizia ; De Vleeschouwer, Steven ; Zitvogel, Laurence ; Kroemer, Guido ; Galluzzi, Lorenzo ; Garg, Abhishek D.
Assuntos: Antigen cross-presentation ; clinical trial ; DAMPs ; immune checkpoint blockers ; plasmacytoid dendritic cells ; Review ; TLR signaling ; tumor-infiltrating lymphocytes
É parte de: Oncoimmunology, 2019-11, Vol.8 (11), p.e1638212-e1638212
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
shared first co-authorship
shared co-corresponding/co-senior authorship
Descrição: Dendritic- cells (DCs) have received considerable attention as potential targets for the development of anticancer vaccines. DC-based anticancer vaccination relies on patient-derived DCs pulsed with a source of tumor-associated antigens (TAAs) in the context of standardized maturation-cocktails, followed by their reinfusion. Extensive evidence has confirmed that DC-based vaccines can generate TAA-specific, cytotoxic T cells. Nonetheless, clinical efficacy of DC-based vaccines remains suboptimal, reflecting the widespread immunosuppression within tumors. Thus, clinical interest is being refocused on DC-based vaccines as combinatorial partners for T cell-targeting immunotherapies. Here, we summarize the most recent preclinical/clinical development of anticancer DC vaccination and discuss future perspectives for DC-based vaccines in immuno-oncology.
Editor: United States: Taylor & Francis
Idioma: Inglês

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Trial watch: dendritic cell vaccination for cancer immunotherapy

Sprooten, Jenny ; Ceusters, Jolien ; Coosemans, An ; Agostinis, Patrizia ; De Vleeschouwer, Steven ; Zitvogel, Laurence ; Kroemer, Guido ; Galluzzi, Lorenzo ; Garg, Abhishek D.

United States: Taylor & Francis

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