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Antinociceptive properties in mice of a lectin isolated from the marine alga Amansia multifida Lamouroux

Neves, S A ; Freitas, A L P ; Sousa, B W ; Rocha, M L A ; Correia, M V O ; Sampaio, D A ; Viana, G S B

Brazilian journal of medical and biological research, 2007-01, Vol.40 (1), p.127-134 [Periódico revisado por pares]

Brazil: Associação Brasileira de Divulgação Científica

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  • Título:
    Antinociceptive properties in mice of a lectin isolated from the marine alga Amansia multifida Lamouroux
  • Autor: Neves, S A ; Freitas, A L P ; Sousa, B W ; Rocha, M L A ; Correia, M V O ; Sampaio, D A ; Viana, G S B
  • Assuntos: Amansia multifida ; Analgesics - isolation & purification ; Analgesics - pharmacology ; Animals ; Antinociceptive effects ; BIOLOGY ; Female ; Lectin ; Male ; Mannose-specific lectin ; MEDICINE, RESEARCH & EXPERIMENTAL ; Mice ; Pain Measurement ; Plant Extracts - pharmacology ; Plant Lectins - isolation & purification ; Plant Lectins - pharmacology ; Red algae ; Rhodophyta - chemistry
  • É parte de: Brazilian journal of medical and biological research, 2007-01, Vol.40 (1), p.127-134
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: The antinociceptive effects of a lectin (LEC) isolated from the marine alga Amansia multifida were determined in Swiss mice. The LEC (1, 5, and 10 mg/kg) inhibited acetic acid-induced abdominal writhings in a dose-dependent manner after intraperitoneal or oral administration. A partial but significant inhibition of writhings was observed after the combination of LEC (10 mg/kg) with avidin (1 mg/kg), a potent inhibitor of the hemmaglutinant activity of the lectin. However, total writhing inhibition was demonstrable in the group of mice treated with LEC plus mannose (1 mg/kg), as compared to LEC alone or to control groups. Furthermore, avidin and mainly mannose also play a role in antinociception, somehow facilitating the interaction of LEC with its active cell sites. In the formalin test, although both phases of the response were significantly inhibited, the effect of LEC was predominant during phase 2, causing inhibition of licking time that ranged from 48 to 88% after oral (5 and 10 mg/kg) and intraperitoneal (1 to 5 mg/kg) administration. As is the case with morphine, the effect of LEC (2 mg/kg) was reversed by naloxone (2 mg/kg), indicating the involvement of the opioid system. LEC was also effective in the hot-plate test, producing inhibitory responses to the thermal stimulus, and its effects were blocked by naloxone. In the pentobarbital-induced sleeping time, although LEC did not alter the onset of sleep significantly, it increased the time of sleep within the same dose range compared to control. These results show that LEC presents antinociceptive effects of both central and peripheral origin, possibly involving the participation of the opioid system.
  • Editor: Brazil: Associação Brasileira de Divulgação Científica
  • Idioma: Inglês;Português
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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