Idioma:

Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models

Nogawa, Masaki ; Yuasa, Takeshi ; Kimura, Shinya ; Kuroda, Junya ; Sato, Kiyoshi ; Segawa, Hidekazu ; Yokota, Asumi ; Maekawa, Taira

Cancer letters, 2005-01, Vol.217 (2), p.243-253 [Periódico revisado por pares]

Ireland: Elsevier Ireland Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models
Autor: Nogawa, Masaki ; Yuasa, Takeshi ; Kimura, Shinya ; Kuroda, Junya ; Sato, Kiyoshi ; Segawa, Hidekazu ; Yokota, Asumi ; Maekawa, Taira
Assuntos: Animals ; Aqueous solutions ; Bioluminescence ; Bisphosphonate ; Cell growth ; Cell Line, Tumor ; Cell Proliferation ; Diagnostic Imaging - methods ; Diphosphonates - pharmacology ; Disease Models, Animal ; Humans ; Imidazoles - pharmacology ; In vivo model ; Luciferase ; Luciferases ; Luminescent Measurements ; Medical research ; Metastasis ; Methods ; Neoplasm Metastasis - diagnosis ; Neoplasm Transplantation ; Neoplasms - drug therapy ; Real time ; Real time imaging ; Rodents ; Studies ; Technological change ; YM529
É parte de: Cancer letters, 2005-01, Vol.217 (2), p.243-253
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Cancer metastasis is infrequently evaluated in vivo, probably because of the few available models and the technical challenges associated with the detection of metastases. Here we show that the growth and metastases of HT1080 fibrosarcoma, A549 lung adenocarcinoma, and RENCA murine renal cancer cell lines in five different in vivo models can be successfully monitored by labeling the cells with luciferase prior to their implantation and then detecting their bioluminesence after injecting luciferin. We also used this in vivo imaging system to successfully demonstrate that YM529, a third generation bisphosphonate, inhibited the growth of sarcoma metastases in bone. We believe the models we have established in combination with the in vivo imaging system will be highly useful for future studies of metastasis and the testing of anti-metastatic therapies.
Editor: Ireland: Elsevier Ireland Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models

Nogawa, Masaki ; Yuasa, Takeshi ; Kimura, Shinya ; Kuroda, Junya ; Sato, Kiyoshi ; Segawa, Hidekazu ; Yokota, Asumi ; Maekawa, Taira

Ireland: Elsevier Ireland Ltd

Buscando em bases de dados remotas. Favor aguardar.