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Saturated fatty acids modulate autophagy's proteins in the hypothalamus

Portovedo, Mariana ; Ignacio-Souza, Letícia M ; Bombassaro, Bruna ; Coope, Andressa ; Reginato, Andressa ; Razolli, Daniela S ; Torsoni, Márcio A ; Torsoni, Adriana S ; Leal, Raquel F ; Velloso, Licio A ; Milanski, Marciane Aguila, Marcia B.

PloS one, 2015-03, Vol.10 (3), p.e0119850-e0119850 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Saturated fatty acids modulate autophagy's proteins in the hypothalamus
Autor: Portovedo, Mariana ; Ignacio-Souza, Letícia M ; Bombassaro, Bruna ; Coope, Andressa ; Reginato, Andressa ; Razolli, Daniela S ; Torsoni, Márcio A ; Torsoni, Adriana S ; Leal, Raquel F ; Velloso, Licio A ; Milanski, Marciane
Aguila, Marcia B.
Assuntos: Analysis of Variance ; Animal Nutritional Physiological Phenomena ; Animals ; Apoptosis ; Autophagy ; Autophagy - physiology ; BAX protein ; bcl-2-Associated X Protein - metabolism ; Brain research ; Cell death ; Cell Line ; Chronic exposure ; Diagnostic systems ; Diet ; Endoplasmic reticulum ; Energy ; Fatty acids ; Fatty Acids - metabolism ; Fluorescent Antibody Technique ; Glucose Tolerance Test ; High fat diet ; Homeostasis ; Hypothalamus ; Hypothalamus - metabolism ; Hypothalamus - physiology ; Immunoblotting ; Inflammation ; Insulin resistance ; JNK protein ; Laboratory animals ; Lipids ; Male ; MAP Kinase Kinase 4 - metabolism ; Metabolism ; Mice ; Mice, Obese ; Neurons ; Nutrition research ; Obesity ; Obesity - physiopathology ; Organelles ; Overnutrition ; Palmitic acid ; Phagocytosis ; Proteins ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Rodents ; Saturated fatty acids ; Science ; Signal transduction ; Weight control
É parte de: PloS one, 2015-03, Vol.10 (3), p.e0119850-e0119850
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: MM LAV. Performed the experiments: MP LMIS BB AC AR DSR. Analyzed the data: MP AST MM. Contributed reagents/materials/analysis tools: RFL MAT LAV. Wrote the paper: MP MM.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Autophagy is an important process that regulates cellular homeostasis by degrading dysfunctional proteins, organelles and lipids. In this study, the hypothesis that obesity could lead to impairment in hypothalamic autophagy in mice was evaluated by examining the hypothalamic distribution and content of autophagic proteins in animal with obesity induced by 8 or 16 weeks high fat diet to induce obesity and in response to intracerebroventricular injections of palmitic acid. The results showed that chronic exposure to a high fat diet leads to an increased expression of inflammatory markers and downregulation of autophagic proteins. In obese mice, autophagic induction leads to the downregulation of proteins, such as JNK and Bax, which are involved in the stress pathways. In neuron cell-line, palmitate has a direct effect on autophagy even without inflammatory activity. Understanding the cellular and molecular bases of overnutrition is essential for identifying new diagnostic and therapeutic targets for obesity.
Editor: United States: Public Library of Science
Idioma: Inglês

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Saturated fatty acids modulate autophagy's proteins in the hypothalamus

Portovedo, Mariana ; Ignacio-Souza, Letícia M ; Bombassaro, Bruna ; Coope, Andressa ; Reginato, Andressa ; Razolli, Daniela S ; Torsoni, Márcio A ; Torsoni, Adriana S ; Leal, Raquel F ; Velloso, Licio A ; Milanski, Marciane Aguila, Marcia B.

United States: Public Library of Science

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