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Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis

Prieto, Laura, M.D ; Quesada, Juan F., M.D ; Cambero, Olivia, M.D ; Pacheco, Alberto, Ph.D ; Pellicer, Antonio, M.D ; Codoceo, Rosa, M.D ; Garcia-Velasco, Juan A., M.D

Fertility and sterility, 2012-07, Vol.98 (1), p.126-130 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis
Autor: Prieto, Laura, M.D ; Quesada, Juan F., M.D ; Cambero, Olivia, M.D ; Pacheco, Alberto, Ph.D ; Pellicer, Antonio, M.D ; Codoceo, Rosa, M.D ; Garcia-Velasco, Juan A., M.D
Assuntos: Adult ; antioxidant activity ; ascorbic acid ; Ascorbic Acid - analysis ; Ascorbic Acid - blood ; Biological and medical sciences ; Biomarkers - analysis ; Biomarkers - blood ; Biomarkers - metabolism ; Birth control ; blood serum ; Case-Control Studies ; eggs ; embryogenesis ; endometriosis ; Endometriosis - blood ; Endometriosis - complications ; Endometriosis - diagnosis ; Endometriosis - metabolism ; Female ; Female genital diseases ; follicular development ; follicular fluid ; Follicular Fluid - chemistry ; Follicular Fluid - metabolism ; Gynecology. Andrology. Obstetrics ; Humans ; infertility ; Infertility, Female - blood ; Infertility, Female - diagnosis ; Infertility, Female - etiology ; Infertility, Female - metabolism ; Internal Medicine ; Male ; malondialdehyde ; Medical sciences ; Non tumoral diseases ; Obstetrics and Gynecology ; Ovarian Diseases - blood ; Ovarian Diseases - complications ; Ovarian Diseases - diagnosis ; Ovarian Diseases - metabolism ; Oxidative stress ; Oxidative Stress - physiology ; patients ; reactive oxygen species ; Sterility. Assisted procreation ; superoxide dismutase ; Superoxide Dismutase - analysis ; Superoxide Dismutase - blood ; Superoxide Dismutase - metabolism ; Superoxide Dismutase-1 ; vitamin E ; women
É parte de: Fertility and sterility, 2012-07, Vol.98 (1), p.126-130
Notas: http://dx.doi.org/10.1016/j.fertnstert.2012.03.052
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Objective To study the levels of four markers of oxidative stress in follicular fluid (FF) and plasma of patients with infertility related to endometriosis and controls. Design Experimental study. Setting University-affiliated hospital and infertility center. Patient(s) Ninety-one infertile women were included in the study (23 infertile women with endometriosis and 68 controls including infertile women due to tubal factor, male factor, or healthy egg donors). Intervention(s) Blood was obtained at the time of egg retrieval, and FF from the mature follicles of each ovary was centrifuged and frozen until analysis. Main Outcome Measure(s) Vitamin C and E, malondialdehyde, and superoxide dismutase concentrations in plasma and follicular fluid. Result(s) Women with endometriosis showed a lower vitamin C concentration in FF (12.7 ± 5.9 vs. 9.7 ± 6.9 μg/mL) and lower superoxide dismutase concentration in plasma (0.9 ± 1.4 vs. 0.5 ± 0.7 U/mL) compared with controls. Vitamin E plasma levels were significantly higher in women with endometriosis (8.1 ± 3.8 vs. 5.2 ± 3.2 μg/mL). A nonsignificant trend toward a lower plasma concentration of malondialdehyde was found in women with endometriosis. Conclusion(s) These findings suggest a lower antioxidant capacity in infertile women with endometriosis. Although a certain level of reactive oxygen species is required under physiological conditions, an altered balance between pro-oxidant and antioxidant activities may have an impact on folliculogenesis and adequate embryo development.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis

Prieto, Laura, M.D ; Quesada, Juan F., M.D ; Cambero, Olivia, M.D ; Pacheco, Alberto, Ph.D ; Pellicer, Antonio, M.D ; Codoceo, Rosa, M.D ; Garcia-Velasco, Juan A., M.D

New York, NY: Elsevier Inc

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