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Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause

ROCCA, W. A ; BOWER, J. H ; MARAGANORE, D. M ; AHLSKOG, J. E ; GROSSARDT, B. R ; DE ANDRADE, M ; MELTON, L. J

Neurology, 2007-09, Vol.69 (11), p.1074-1083 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause
Autor: ROCCA, W. A ; BOWER, J. H ; MARAGANORE, D. M ; AHLSKOG, J. E ; GROSSARDT, B. R ; DE ANDRADE, M ; MELTON, L. J
Assuntos: Adult ; Age Factors ; Aged ; Aging ; Biological and medical sciences ; Causality ; Cognition Disorders - epidemiology ; Cognition Disorders - etiology ; Cognition Disorders - physiopathology ; Cohort Studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia - epidemiology ; Dementia - etiology ; Dementia - physiopathology ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Estrogens - metabolism ; Female ; Humans ; Interviews as Topic ; Medical sciences ; Menopause, Premature - metabolism ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Neuroprotective Agents - metabolism ; Ovariectomy - adverse effects ; Risk Factors ; Surveys and Questionnaires
É parte de: Neurology, 2007-09, Vol.69 (11), p.1074-1083
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Descrição: There is increasing laboratory evidence for a neuroprotective effect of estrogen; however, the clinical and epidemiologic evidence remains limited and conflicting. We studied the association of oophorectomy performed before the onset of menopause with the risk of subsequent cognitive impairment or dementia. We included all women who underwent unilateral or bilateral oophorectomy before the onset of menopause for a non-cancer indication while residing in Olmsted County, MN, from 1950 through 1987. Each member of the oophorectomy cohort was matched by age to a referent woman from the same population who had not undergone oophorectomy. In total, we studied 813 women with unilateral oophorectomy, 676 women with bilateral oophorectomy, and 1,472 referent women. Women were followed through death or end of study using either direct or proxy interviews. Women who underwent either unilateral or bilateral oophorectomy before the onset of menopause had an increased risk of cognitive impairment or dementia compared to referent women (hazard ratio [HR] = 1.46; 95% CI 1.13 to 1.90; adjusted for education, type of interview, and history of depression). The risk increased with younger age at oophorectomy (test for linear trend; adjusted p < 0.0001). These associations were similar regardless of the indication for the oophorectomy, and for women who underwent unilateral or bilateral oophorectomy considered separately. Both unilateral and bilateral oophorectomy preceding the onset of menopause are associated with an increased risk of cognitive impairment or dementia. The effect is age-dependent and suggests a critical age window for neuroprotection.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause

ROCCA, W. A ; BOWER, J. H ; MARAGANORE, D. M ; AHLSKOG, J. E ; GROSSARDT, B. R ; DE ANDRADE, M ; MELTON, L. J

Hagerstown, MD: Lippincott Williams & Wilkins

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