skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Propofol at Single Bolus and Continuous Rate Infusion Significantly Increases Serum Triglycerides, but not Cholesterol, In Healthy Bitches Undergoing Elective Ovariohysterectomy

Chagas, MA ; Custodio, LP ; Gusmão, BS ; Costa, IM ; Julião, GH ; Bordolini, SLS ; Costa, LR ; Bosculo, MRM ; Moreira, TF ; Almeida, BFM ; Reis Filho, NP ; Romão, FG ; Abimussi, CJX ; Floriano, BP

Topics in companion animal medicine, 2021-11, Vol.45, p.100560-100560, Article 100560 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por
  • Título:
    Propofol at Single Bolus and Continuous Rate Infusion Significantly Increases Serum Triglycerides, but not Cholesterol, In Healthy Bitches Undergoing Elective Ovariohysterectomy
  • Autor: Chagas, MA ; Custodio, LP ; Gusmão, BS ; Costa, IM ; Julião, GH ; Bordolini, SLS ; Costa, LR ; Bosculo, MRM ; Moreira, TF ; Almeida, BFM ; Reis Filho, NP ; Romão, FG ; Abimussi, CJX ; Floriano, BP
  • Assuntos: Anesthesia ; Anesthesia - veterinary ; Animals ; Blood pressure ; Cholesterol ; dog ; Dogs ; Drug delivery systems ; Drug dosages ; Female ; general anesthesia ; hypercholesterolemia ; hyperlipidemia ; hypertriglyceridemia ; Hysterectomy - veterinary ; Intravenous administration ; Lipids ; Morphine ; Normality ; Propofol ; Propofol - pharmacology ; Spasticity ; Triglycerides
  • É parte de: Topics in companion animal medicine, 2021-11, Vol.45, p.100560-100560, Article 100560
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: •The lipid emulsion of propofol at 1% produces significant increases in serum triglyceride levels and causes lipemia in healthy bitches undergoing elective ovariohysterectomy•Serum cholesterol significantly decreased at TIND and TCRI, although no difference was found between TIND and TCRI.•Triglycerides significantly increased at TIND and at TCRI compared to TPM but only TCRI differed from TB. This study aimed to investigate the effects of a single bolus and continuous rate infusion (CRI) of 1% propofol on cholesterol and triglyceride levels of healthy bitches undergoing elective ovariohysterectomy. 10 healthy bitches undergoing elective ovariohysterectomy had blood samples obtained at baseline (TB), 15 minutes following premedication with acepromazine and morphine (TPM), after an intravenous bolus of propofol (induction to anesthesia, TIND) and following 90 minutes of CRI of propofol started at 0.4 mg kg−1 min−1 and adjusted according to individual requirements (TCRI). Data were initially tested for normality using the Shapiro-Wilk test, and comparisons were performed using Friedman followed by Dunn post-hoc test. Serum cholesterol levels significantly decreased at TIND and TCRI (median [min-max] 201 mg dL−1 [111-234 mg dL−1], and 215 mg dL−1 [111-239 mg dL−1]), respectively, compared with TB (232 [128-245 mg dL−1]) and TPM (206 [115-255 mg dL−1]). No differences were found between TIND and TCRI. Triglyceride levels increased significantly at TIND (120 [67-231 mg dL−1]) and TCRI (229 [73-549 mg dL−1]) compared with TPM (36 [51-29 mg dL−1]), and TCRI compared with TB. In conclusion, 1% propofol lipid emulsion significantly increases serum triglycerides and causes lipemia in healthy dogs at a single bolus or CRI.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.