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Tissue remodeling in Guinea pig lateral prostate at different ages after estradiol treatment

Scarano, Wellerson Rodrigo ; Cordeiro, Renato Simões ; Góes, Rejane Maira ; Carvalho, Hernandes F. ; Taboga, Sebastião Roberto

Cell biology international, 2005-09, Vol.29 (9), p.778-784 [Periódico revisado por pares]

Oxford, UK: Elsevier Ltd

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Título:
Tissue remodeling in Guinea pig lateral prostate at different ages after estradiol treatment
Autor: Scarano, Wellerson Rodrigo ; Cordeiro, Renato Simões ; Góes, Rejane Maira ; Carvalho, Hernandes F. ; Taboga, Sebastião Roberto
Assuntos: Age Factors ; Animals ; BPH ; Collagen - metabolism ; Collagen fibrils ; Disease Models, Animal ; Epithelial Cells - drug effects ; Epithelial Cells - metabolism ; Epithelial Cells - pathology ; Estradiol ; Estradiol - pharmacology ; Estradiol - physiology ; Guinea pig ; Guinea Pigs ; Male ; Microscopy, Electron, Transmission ; Myocytes, Smooth Muscle - drug effects ; Myocytes, Smooth Muscle - pathology ; Prostate ; Prostate - drug effects ; Prostatic Hyperplasia - etiology ; Stroma ; Stromal Cells - drug effects ; Stromal Cells - pathology
É parte de: Cell biology international, 2005-09, Vol.29 (9), p.778-784
Notas: ArticleID:CBIN1690
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SourceType-Scholarly Journals-1
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Descrição: Estrogen seems to have an essential role in the fibromuscular growth characteristic of benign prostatic hyperplasia (BPH). This paper describes the effects of chronic estradiol treatment on Guinea pig prostatic stroma at different ages. Tissues from experimental animals were studied by histological and histochemical procedures, morphometric–stereological analysis and transmission electron microscopy (TEM). Marked fibromuscular hypertrophy was observed after estradiol treatment in animals of pre-pubertal and adult ages. Increases in the density and thickness of the collagen and elastic fibers were observed by histochemistry. TEM revealed wide distributions of collagen fibrils and large elastic fibers adjacent to the epithelial basal lamina and between the stromal cells, establishing contacts between them. These results indicate that the Guinea pig prostate simulates the stromal modifications observed in BPH in some aged animals after estrogen treatment at different ages, making it a good model for this disease.
Editor: Oxford, UK: Elsevier Ltd
Idioma: Inglês

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Tissue remodeling in Guinea pig lateral prostate at different ages after estradiol treatment

Scarano, Wellerson Rodrigo ; Cordeiro, Renato Simões ; Góes, Rejane Maira ; Carvalho, Hernandes F. ; Taboga, Sebastião Roberto

Oxford, UK: Elsevier Ltd

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