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Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

Kong, Xiang-Zhen ; Mathias, Samuel R. ; Guadalupe, Tulio ; Glahn, David C. ; Franke, Barbara ; Crivello, Fabrice ; Tzourio-Mazoyer, Nathalie ; Fisher, Simon E. ; Thompson, Paul M. ; Francks, Clyde

Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (22), p.E5154-E5163 [Periódico revisado por pares]

United States: National Academy of Sciences

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Título:
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
Autor: Kong, Xiang-Zhen ; Mathias, Samuel R. ; Guadalupe, Tulio ; Glahn, David C. ; Franke, Barbara ; Crivello, Fabrice ; Tzourio-Mazoyer, Nathalie ; Fisher, Simon E. ; Thompson, Paul M. ; Francks, Clyde
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asymmetry ; Behavior disorders ; Biological Sciences ; Brain ; Brain architecture ; Brain mapping ; Cerebral Cortex - diagnostic imaging ; Cerebral dominance ; Child ; Child, Preschool ; Cognitive ability ; Cognitive science ; Consortia ; Cortex (entorhinal) ; Databases, Factual - statistics & numerical data ; Datasets ; Disorders ; Dominància cerebral ; Emotional disorders ; Female ; Frontal gyrus ; Gene mapping ; Genetics ; Handedness ; Hemispheric laterality ; Heritability ; Humans ; Infant ; Lateralitat ; Laterality ; Magnetic resonance imaging ; Male ; Medical imaging ; Medicin och hälsovetenskap ; Mental disorders ; Middle Aged ; Neuroimaging ; Neuroimaging - methods ; Neurological diseases ; Neurology ; Neuroscience ; Parahippocampal gyrus ; Pedigree ; PNAS Plus ; Psychiatry ; Psykiatri ; Surface area ; Temporal cortex ; Temporal gyrus ; Variability ; Young Adult
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (22), p.E5154-E5163
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
PMCID: PMC5984496
Edited by Michael B. Miller, University of California, Santa Barbara, and accepted by Editorial Board Member Michael S. Gazzaniga April 6, 2018 (received for review October 29, 2017)
Author contributions: X.-Z.K., T.G., S.E.F., P.M.T., and C.F. designed research; X.-Z.K., E.L.W.G., D.C.G., B.F., N.T.-M., and C.F. performed research; X.-Z.K., S.R.M., T.G., E.L.W.G., and F.C. analyzed data; and X.-Z.K., S.R.M., E.L.W.G., D.C.G., B.F., F.C., N.T.-M., S.E.F., P.M.T., and C.F. wrote the paper.
Descrição: Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.
Editor: United States: National Academy of Sciences
Idioma: Inglês

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Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

Kong, Xiang-Zhen ; Mathias, Samuel R. ; Guadalupe, Tulio ; Glahn, David C. ; Franke, Barbara ; Crivello, Fabrice ; Tzourio-Mazoyer, Nathalie ; Fisher, Simon E. ; Thompson, Paul M. ; Francks, Clyde

United States: National Academy of Sciences

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