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Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior

Guerra-Gomes, Sónia ; Sousa, Nuno ; Pinto, Luísa ; Oliveira, João F

Frontiers in cellular neuroscience, 2018-01, Vol.11, p.427-427 [Periódico revisado por pares]

Switzerland: Frontiers Research Foundation

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  • Título:
    Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior
  • Autor: Guerra-Gomes, Sónia ; Sousa, Nuno ; Pinto, Luísa ; Oliveira, João F
  • Assuntos: astrocyte ; Astrocytes ; behavior ; Biochemistry ; Calcium ; neural circuit ; Neuroscience ; Physiology ; synapse ; Synaptic plasticity ; Synaptic transmission
  • É parte de: Frontiers in cellular neuroscience, 2018-01, Vol.11, p.427-427
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    Edited by: Kira Poskanzer, University of California, San Francisco, United States
    Reviewed by: Hajime Hirase, RIKEN Brain Science Institute, Japan; Vladislav Volman, L-3 Communications, United States; Alfonso Araque, University of Minnesota, United States
  • Descrição: Astrocytes are fundamental players in the regulation of synaptic transmission and plasticity. They display unique morphological and phenotypical features that allow to monitor and to dynamically respond to changes. One of the hallmarks of the astrocytic response is the generation of calcium elevations, which further affect downstream cellular processes. Technical advances in the field have allowed to spatially and to temporally quantify and qualify these elevations. However, the impact on brain function remains poorly understood. In this review, we discuss evidences of the functional impact of heterogeneous astrocytic calcium events in several brain regions, and their consequences in synapses, circuits, and behavior.
  • Editor: Switzerland: Frontiers Research Foundation
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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