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Zero-contrast imaging for the assessment of transcatheter aortic valve implantation in candidates with renal dysfunction

Prado, Guy F. A. ; Garzon, Stefano ; Mariani, Jose ; Caixeta, Adriano ; O. Almeida, Breno ; O. Ramalho, Felipe ; C. Vieira, Marcelo L. ; Fischer, Claudio H. ; Szarf, Gilberto ; Ishikawa, Walther ; Lemos, Pedro A.

Renal Failure, 2023, Vol.45 (1)

Taylor & Francis

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  • Título:
    Zero-contrast imaging for the assessment of transcatheter aortic valve implantation in candidates with renal dysfunction
  • Autor: Prado, Guy F. A. ; Garzon, Stefano ; Mariani, Jose ; Caixeta, Adriano ; O. Almeida, Breno ; O. Ramalho, Felipe ; C. Vieira, Marcelo L. ; Fischer, Claudio H. ; Szarf, Gilberto ; Ishikawa, Walther ; Lemos, Pedro A.
  • Assuntos: Aortic stenosis ; contrast-induced nephropathy ; renal failure ; transcatheter aortic valve implantation
  • É parte de: Renal Failure, 2023, Vol.45 (1)
  • Descrição: Candidates for transcatheter aortic valve implantation (TAVI) are currently evaluated using computed tomography angiography and invasive cardiac catheterization as an essential part of case selection and pre-procedure interventional planning. However, both imaging methods utilize iodinated agents, which may cause contrast-induced nephropathy, particularly in patients with baseline renal dysfunction. This study aimed to describe a zero-contrast imaging protocol for pre-TAVI evaluation in patients with advanced renal impairment. The pre-TAVI zero-contrast scheme consisted of the following multi-modality combinations: (1) gadolinium-free magnetic resonance imaging (three-dimensional navigator-echo with electrocardiogram-gated steady-state free-precession series); (2) iodinated-free multislice computed tomography electrocardiogram-gated; (3) lower limb arterial duplex scan ultrasound; and (4) transesophageal echocardiography. Ultimately, TAVI was performed for those deemed good candidates, and contrast was allowed during the intervention; however, operators were strongly advised to utilize the least volume possible of iodinated agents. This pilot survey included ten patients with symptomatic aortic stenosis and renal dysfunction who underwent zero-contrast multi-modality imaging. All the patients ultimately underwent TAVI. The intervention was successful in all cases, without ≥ moderate residual aortic regurgitation, prosthesis embolization, annulus rupture, major vascular complications, stroke, or death during index hospitalization. The creatinine clearance remained stable throughout the observation period (baseline: 26.85 ± 12.55 mL/min; after multi-modality imaging: 26.76 ± 11.51 mL/min; post-TAVI at discharge: 29.84 ± 13.98 mL/min; p = 0.3 all). The proposed contrast-free imaging protocol appears to be a promising clinical tool for pre-TAVI evaluation in patients with severe renal dysfunction.
  • Editor: Taylor & Francis
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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