skip to main content
Idioma:

Human erythrocytes as nanoparticle carriers for magnetic particle imaging

Markov, D E ; Boeve, H ; Gleich, B ; Borgert, J ; Antonelli, A ; Sfara, C ; Magnani, M

Physics in medicine & biology, 2010-11, Vol.55 (21), p.6461-6473 [Periódico revisado por pares]

England: IOP Publishing

Texto completo disponível

Citações Citado por
  • Título:
    Human erythrocytes as nanoparticle carriers for magnetic particle imaging
  • Autor: Markov, D E ; Boeve, H ; Gleich, B ; Borgert, J ; Antonelli, A ; Sfara, C ; Magnani, M
  • Assuntos: Benchmarking ; Biomimetics ; Erythrocytes - metabolism ; Ferric Compounds - chemistry ; Humans ; Magnetic Resonance Spectroscopy ; Magnetics ; Microscopy, Electron, Scanning ; Molecular Imaging - methods ; Nanoparticles ; Vibration
  • É parte de: Physics in medicine & biology, 2010-11, Vol.55 (21), p.6461-6473
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: The potential of red blood cells (RBCs) loaded with iron oxide nanoparticles as a tracer material for magnetic particle imaging (MPI) has been investigated. MPI is an emerging, quantitative medical imaging modality which holds promise in terms of sensitivity in combination with spatial and temporal resolution. Steady-state and dynamic magnetization measurements, supported by semi-empirical modeling, were employed to analyze the MPI signal generation using RBCs as novel biomimetic constructs. Since the superparamagnetic iron oxide (SPIO) bulk material that is used in this study contains nanoparticles with different sizes, it is suggested that during the RBC loading procedure, a preferential entrapment of nanoparticles with hydrodynamic diameter ≤60 nm occurs by size-selection through the erythrocyte membrane pores. This affects the MPI signal of an erythrocyte-based tracer, compared to bulk. The reduced signal is counterbalanced by a higher in vivo stability of the SPIO-loaded RBCs constructs for MPI applications.
  • Editor: England: IOP Publishing
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.