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Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice

Silvério, Renata ; Barth, Robson ; Heimann, Andrea S ; Reckziegel, Patrícia ; Dos Santos, Gustavo J ; Romero-Zerbo, Silvana Y ; Bermúdez-Silva, Francisco J ; Rafacho, Alex ; Ferro, Emer S

International journal of molecular sciences, 2022-04, Vol.23 (8), p.4082 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice
Autor: Silvério, Renata ; Barth, Robson ; Heimann, Andrea S ; Reckziegel, Patrícia ; Dos Santos, Gustavo J ; Romero-Zerbo, Silvana Y ; Bermúdez-Silva, Francisco J ; Rafacho, Alex ; Ferro, Emer S
Assuntos: Adipose tissue ; Adipose tissue (brown) ; Adipose Tissue - metabolism ; Adipose Tissue, Brown - metabolism ; Adipose Tissue, White - metabolism ; Alanine ; Alanine transaminase ; Animal models ; Animals ; bioactive peptides ; Body fat ; Central nervous system ; Diet ; Diet, High-Fat - adverse effects ; Food ; Gene expression ; Glucose ; High fat diet ; Insulin ; Insulin Resistance ; intracellular peptides ; Kinases ; Laboratory animals ; Liver ; Liver - metabolism ; Male ; Mathematical models ; Metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Nerve Tissue Proteins ; Nervous system ; Obesity ; Obesity - drug therapy ; Obesity - etiology ; Obesity - metabolism ; Oral administration ; orally active peptides ; Overweight ; Parameters ; Peptides ; Phenotype ; Phenotypes ; Sensitivity ; Uncoupling protein 1 ; Weight control ; Weight reduction
É parte de: International journal of molecular sciences, 2022-04, Vol.23 (8), p.4082
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Peptide DIIADDEPLT (Pep19) has been previously suggested to improve metabolic parameters, without adverse central nervous system effects, in a murine model of diet-induced obesity. Here, we aimed to further evaluate whether Pep19 oral administration has anti-obesogenic effects, in a well-established high-fat diet-induced obesity model. Male Swiss mice, fed either a standard diet (SD) or high-fat diet (HFD), were orally administrated for 30 consecutive days, once a day, with saline vehicle or Pep19 (1 mg/kg). Next, several metabolic, morphological, and behavioral parameters were evaluated. Oral administration of Pep19 attenuated HFD body-weight gain, reduced in approximately 40% the absolute mass of the endocrine pancreas, and improved the relationship between circulating insulin and peripheral insulin sensitivity. Pep19 treatment of HFD-fed mice attenuated liver inflammation, hepatic fat distribution and accumulation, and lowered plasma alanine aminotransferase activity. The inguinal fat depot from the SD group treated with Pep19 showed multilocular brown-fat-like cells and increased mRNA expression of uncoupling protein 1 (UCP1), suggesting browning on inguinal white adipose cells. Morphological analysis of brown adipose tissue (BAT) from HFD mice showed the presence of larger white-like unilocular cells, compared to BAT from SD, Pep19-treated SD or HFD mice. Pep19 treatment produced no alterations in mice behavior. Oral administration of Pep19 ameliorates some metabolic traits altered by diet-induced obesity in a Swiss mice model.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice

Silvério, Renata ; Barth, Robson ; Heimann, Andrea S ; Reckziegel, Patrícia ; Dos Santos, Gustavo J ; Romero-Zerbo, Silvana Y ; Bermúdez-Silva, Francisco J ; Rafacho, Alex ; Ferro, Emer S

Switzerland: MDPI AG

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